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Structure of eEF3 and the mechanism of transfer RNA release from the E-site
Elongation factor eEF3 is an ATPase that, in addition to the two canonical factors eEF1A and eEF2, serves an essential function in the translation cycle of fungi. eEF3 is required for the binding ofExpand
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Mechanism of eIF6-mediated Inhibition of Ribosomal Subunit Joining*
During the process of ribosomal assembly, the essential eukaryotic translation initiation factor 6 (eIF6) is known to act as a ribosomal anti-association factor. However, a molecular understanding ofExpand
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Following the signal sequence from ribosomal tunnel exit to signal recognition particle
Membrane and secretory proteins can be co-translationally inserted into or translocated across the membrane. This process is dependent on signal sequence recognition on the ribosome by the signalExpand
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Fluorine-18: a new isotope for bone scanning.
The possibility of detecting bone lesions by isotope scanning after the administration of F/sup 18/ is discussed. The ies, preparation, and half life of F/sup 18/ are reviewed. Eighteen patients withExpand
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Circulating proteasomes are functional and have a subtype pattern distinct from 20S proteasomes in major blood cells.
BACKGROUND 20S proteasomes, the proteolytic core particles of the major intracellular protein degradative pathway, are potential disease markers because they are detectable in human plasma asExpand
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18 F-fluoride for bone imaging.
This report summarizes 10 yr of experience with 18 F for bone scanning. The fluoride ion is rapidly taken up by an exchange process with bone which is a function of blood flow and exposure of boneExpand
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Radiation dose to humans from 75 Se-L-selenomethionine.
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A new brain perfusion imaging agent: [I-123]HIPDM:N,N,N'-trimethyl-N'-[2-hydroxy-3-methyl-5-iodobenzyl]-1,3-propanediamine.
Based on the pH-shift mechanism, a new brain imaging agent I-124 HIPDM (N,N,N'-trimethyl-N'-[2-hydroxy-3-methyl-5-[123I]iodobenzyl]-1,3-propanediamine ) has been developed. This agent can be preparedExpand
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Regional intracellular pH shift: a proposed new mechanism for radiopharmaceutical uptake in brain and other tissues.
  • H. Kung, M. Blau
  • Chemistry, Medicine
  • Journal of nuclear medicine : official…
  • 1 February 1980
This paper proposes a new mechanism for radiopharmaceutical uptake, which may be applicable to a variety of clinical studies. Many tissues and organs have low intracellular pH, either normally or asExpand
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ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane
Ribosomes translating secretory and membrane proteins are targeted to the endoplasmic reticulum membrane and attach to the protein-conducting channel and ribosome-associated membrane proteinsExpand
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