Structure, Function and Diversity of the Healthy Human Microbiome
The Human Microbiome Project has analysed the largest cohort and set of distinct, clinically relevant body habitats so far, finding the diversity and abundance of each habitat’s signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals.
Advances in the detection of the presence of the organism and methods of differentiating among types of H. pylori are highlighted, and a background for appropriate chemotherapy of the infection is provided.
Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori
- J. Atherton, P. Cao, R. Peek, M. Tummuru, M. Blaser, T. Cover
- BiologyJournal of Biological Chemistry
- 28 July 1995
Specific vacA genotypes of H. pylori strains are associated with the level of in vitro cytotoxin activity as well as clinical consequences, which implies that recombination has occurred in vivo between vacA alleles.
The human microbiome: at the interface of health and disease
The large-scale dynamics of the microbiome can be described by many of the tools and observations used in the study of population ecology, andiphering the metagenome and its aggregate genetic information can also be used to understand the functional properties of the microbial community.
Experimental Campylobacter jejuni infection in humans.
- R. Black, M. Levine, M. Clements, T. Hughes, M. Blaser
- MedicineJournal of Infectious Diseases
- 1 March 1988
Two strains of Campylobacter jejuni ingested by 111 adult volunteers, in doses ranging from 8 x 10(2) to 2x 10(9) organisms, caused diarrheal illnesses that indicates that the pathogenesis of C.Jejuni infection includes tissue inflammation.
Sparse and Compositionally Robust Inference of Microbial Ecological Networks
- Zachary D. Kurtz, Christian L. Müller, Emily R. Miraldi, D. Littman, M. Blaser, Richard Bonneau
- Environmental SciencePLoS Comput. Biol.
- 18 August 2014
SParse InversE Covariance Estimation for Ecological Association Inference is presented, a statistical method for the inference of microbial ecological networks from amplicon sequencing datasets that outperforms state-of-the-art methods to recover edges and network properties on synthetic data under a variety of scenarios.
Traces of Human Migrations in Helicobacter pylori Populations
Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations derive…
Molecular analysis of the bacterial microbiota in the human stomach.
- E. Bik, P. Eckburg, D. Relman
- Biology, MedicineProceedings of the National Academy of Sciences…
- 17 January 2006
Bacterial diversity within the human gastric mucosa was characterized by using a small subunit 16S rDNA clone library approach and sequences generated by broad-range bacterial PCR from 23 gastric endoscopic biopsy samples were analyzed, featuring diversity at this site greater than previously described.
Guillain-Barré syndrome in northern China. Relationship to Campylobacter jejuni infection and anti-glycolipid antibodies.
No statistically significant correlations were found between the pattern of disease, AMAN or AIDP, anti-glycolipid antibodies, or C. jejuni antibodies.
Antibiotics in early life alter the murine colonic microbiome and adiposity
A model of adiposity is generated by giving subtherapeutic antibiotic therapy to young mice and changes in the composition and capabilities of the gut microbiome are evaluated, demonstrating the alteration of early-life murine metabolic homeostasis through antibiotic manipulation.