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Molybdenum-dependent degradation of quinoline by Pseudomonas putida Chin IK and other aerobic bacteria
TLDR
Partially purified quinoline dehydrogenase from Pseudomonas putida Chin IK indicated the presence of flavin, iron-sulfur centers, and molybdenum-binding pterin. Expand
Structural and Functional Characterization of Sapovirus RNA-Dependent RNA Polymerase
TLDR
The first extensive characterization of the key enzyme of replication, the RNA-dependent RNA polymerase (RdRp) associated with the 3Dpol-like protein is reported here on, suggesting structural and functional homologies in the RNAs of human pathogenic calicivirus infection in humans. Expand
Pharmacokinetics of a synthetic, chemically modified hammerhead ribozyme against the rat cytochrome P-450 3A2 mRNA after single intravenous injections.
TLDR
Data support the potential utility of synthetic, 2'-O-allyl-modified hammerhead ribozymes as therapeutic agents in vivo and show no morphological evidence of toxicity. Expand
Inosine(15.1) hammerhead ribozymes for targeting the transthyretin-30 mutation.
TLDR
The development of this NCH specific hammerhead ribozyme represents a promising tool for future in vivo therapeutic application for TTR-met30 induced hereditary amyloidosis. Expand
Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response
TLDR
During the non-bacterial acute phase, iron content in the liver and brain increased together with the expression of TfR1 and the iron metabolism proteins were regulated in a way similar to that observed in the Liver. Expand
Immunodetection of cyclooxygenase-2 (COX-2) is restricted to tissue macrophages in normal rat liver and to recruited mononuclear phagocytes in liver injury and cholangiocarcinoma
TLDR
Inflammatory mononuclear phagocytes contribute to the increase of COX-2 gene expression in acute and chronic liver damage induced by different toxins and in the CC microenvironment. Expand
Ferroportin-1 is a ‘nuclear’-negative acute-phase protein in rat liver: a comparison with other iron-transport proteins
TLDR
It is demonstrated that liver behaves as a ‘sponge’ for iron under acute-phase conditions, and Fpn-1 behavesAs a negative acute- phase protein in rat hepatocytes mainly, but not exclusively, because of the effect of IL-6. Expand
Immune cells in primary and metastatic gastrointestinal stromal tumors (GIST).
TLDR
Tissue microarrays from 196 patients, 188 primary and 51 metastasized GIST were constructed for paraffin staining and the highest transcript expression was seen for monocyte chemotactic protein 1, macrophage inflammatory protein 1α (MIP-1α/CCL3) and the pro-angiogenic growth-related oncoprotein 1 (Gro-α/CXCL-1). Expand
Measurements of 5-FU Plasma Concentrations in Patients with Gastrointestinal Cancer: 5-FU Levels Reflect the 5-FU Dose Applied
TLDR
With critical analysis of the measurements and correct performance of blood sampling, the measurement of 5-FU plasma concentrations with the immunoassay may in the future allow to optimize 4-FU dosing and to identify the cause of toxicity. Expand
Extending the cleavage rules for the hammerhead ribozyme: mutating adenosine15.1 to inosine15.1 changes the cleavage site specificity from N16.2U16.1H17 to N16.2C16.1H17.
TLDR
It is shown that an adenosine to inosine mutation at position 15.1 changes the substrate specificity of the hammerhead ribozyme, extending the hammer head cleavage triplet definition from N16.2U16.1H17 to the more general N 16.2C16. Expand
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