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Beyond the brain: widespread pathology in Huntington's disease
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a polyglutamine stretch in the huntingtin protein. Today, more than 15 years after the genetic defect underlying HD wasExpand
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Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.
Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potentialExpand
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CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.
Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic peptide widely expressed in the central, peripheral, and enteric nervous systems. CART is also expressed in endocrine cells,Expand
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Abnormal peripheral chemokine profile in Huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain andExpand
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Harnessing Immune Alterations in Neurodegenerative Diseases
Immune dysfunction, a well-established feature of neuroinflammatory disease, is increasingly recognized in neurodegenerative conditions. Its role is emerging as an early and active participant inExpand
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Cell-specific Processing of Chromogranin A in Endocrine Cells of the Rat Stomach
The rat stomach is rich in endocrine cells. The acid-producing (oxyntic) mucosa contains ECL cells, A-like cells, and somatostatin (D) cells, and the antrum harbours gastrin (G) cells,Expand
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Cerebrospinal fluid levels of orexin‐A are not a clinically useful biomarker for Huntington disease
To the Editor: Huntington disease (HD) is a progressive neurodegenerative disorder caused by a CAG triplet repeat expansion in the HD (IT15) gene. No treatment is currently available thatExpand
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Islet β-cell area and hormone expression are unaltered in Huntington’s disease
Neurodegenerative disorders are often associated with metabolic alterations. This has received little attention, but might be clinically important because it can contribute to symptoms and influenceExpand
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Immune markers for Huntington’s disease?
Huntington’s disease (HD) is a devastating, inherited neurodegenerative disorder for which there is no effective treatment. It is caused by a polyglutamine repeat expansion in the gene encoding theExpand
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JAK/STAT Signalling in Huntington’s Disease Immune Cells
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Both central and peripheral innate immune activation have beenExpand
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