M. Birch

Publications119
h-index24
Citations2,033
Highly Influential Citations58
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Vascular endothelial growth factor receptors in osteoclast differentiation and function.
Osteoclasts are derived from haematopoietic stem cell precursors of the monocyte/macrophage cell lineage, through interaction with factors that are believed to include M-CSF and RANKL. VEGF is a… Expand
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Microcellular polyHIPE polymer supports osteoblast growth and bone formation in vitro.
A novel micro-cellular polymer with a well-defined and uniform micro-architecture has been developed as a three-dimensional support matrix for in vitro tissue engineering applications. This material… Expand
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The enhancement of osteoblast growth and differentiation in vitro on a peptide hydrogel-polyHIPE polymer hybrid material.
The objective of this study was to investigate the effect of combining two biomaterials on osteoblast proliferation, differentiation and mineralised matrix formation in vitro. The first biomaterial… Expand
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Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone.
Signaling between the various types of cells found in bone is responsible for controlling the activity of osteoblasts and osteoclasts, and therefore the regulation of bone mass. Our identification of… Expand
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Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor expression and mitogenic responses in human breast cancer cell lines.
Previous reports have shown the production of parathyroid hormone-related protein (PTHrP) by breast cancer cells in vivo and in vitro. We have investigated the expression of the PTH/PTHrP receptor by… Expand
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Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bone
Vascular endothelial growth factor (VEGF) is a proangiogenic cytokine that is expressed highly in many solid tumours often correlating with a poor prognosis. In this study, we investigated the… Expand
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PCR detection of cytokines in normal human and pagetic osteoblast‐like cells
We investigated the expression of cytokine transcripts in osteoblast‐like cells derived from explants of pagetic and normal bone. A reverse transcription‐linked PCR was used that allowed the… Expand
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Expression and secretion of parathyroid hormone‐related protein by human bone‐derived cells in vitro: Effects of glucocorticoids
We investigated the production of parathyroid hormone‐related protein (PTHrP) by cells derived from explants of human bone. Using an immunoradiometric assay (IRMA), PTHrP was detected in conditioned… Expand
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Osteoblast-derived acetylcholinesterase: a novel mediator of cell-matrix interactions in bone?
The adhesive interactions that occur between bone cells and the developing matrix during bone formation help guide coupled remodeling and the maintenance of bone mass. Here, we provide evidence that… Expand
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Absence of paramyxovirus RNA in cultures of pagetic bone cells and in pagetic bon
It has been proposed that Paget's disease of bone is caused by the infection of bone cells with one or several paramyxoviruses. In this study we used the polymerase chain reaction (PCR), which allows… Expand
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