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- Publications
- Influence
Vascular endothelial growth factor receptors in osteoclast differentiation and function.
- S. Aldridge, T. Lennard, J. Williams, M. Birch
- Biology, Medicine
- Biochemical and biophysical research…
- 30 September 2005
Osteoclasts are derived from haematopoietic stem cell precursors of the monocyte/macrophage cell lineage, through interaction with factors that are believed to include M-CSF and RANKL. VEGF is a… Expand
Microcellular polyHIPE polymer supports osteoblast growth and bone formation in vitro.
- G. Akay, M. Birch, M. Bokhari
- Materials Science, Medicine
- Biomaterials
- 1 August 2004
A novel micro-cellular polymer with a well-defined and uniform micro-architecture has been developed as a three-dimensional support matrix for in vitro tissue engineering applications. This material… Expand
The enhancement of osteoblast growth and differentiation in vitro on a peptide hydrogel-polyHIPE polymer hybrid material.
- M. Bokhari, G. Akay, S. Zhang, M. Birch
- Materials Science, Medicine
- Biomaterials
- 1 September 2005
The objective of this study was to investigate the effect of combining two biomaterials on osteoblast proliferation, differentiation and mineralised matrix formation in vitro. The first biomaterial… Expand
Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone.
- A. J. Patton, P. Genever, M. Birch, L. Suva, T. Skerry
- Biology, Medicine
- Bone
- 1 June 1998
Signaling between the various types of cells found in bone is responsible for controlling the activity of osteoblasts and osteoclasts, and therefore the regulation of bone mass. Our identification of… Expand
Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor expression and mitogenic responses in human breast cancer cell lines.
- M. Birch, J. Carron, M. Scott, W. Fraser, J. Gallagher
- Biology, Medicine
- British Journal of Cancer
- 1 July 1995
Previous reports have shown the production of parathyroid hormone-related protein (PTHrP) by breast cancer cells in vivo and in vitro. We have investigated the expression of the PTH/PTHrP receptor by… Expand
Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bone
- S. Aldridge, T. Lennard, J. Williams, M. Birch
- Medicine
- British Journal of Cancer
- 5 April 2005
Vascular endothelial growth factor (VEGF) is a proangiogenic cytokine that is expressed highly in many solid tumours often correlating with a poor prognosis. In this study, we investigated the… Expand
PCR detection of cytokines in normal human and pagetic osteoblast‐like cells
- M. Birch, A. Ginty, C. A. Walsh, W. Fraser, J. Gallagher, G. Bilbe
- Biology, Medicine
- Journal of bone and mineral research : the…
- 1 October 1993
We investigated the expression of cytokine transcripts in osteoblast‐like cells derived from explants of pagetic and normal bone. A reverse transcription‐linked PCR was used that allowed the… Expand
Expression and secretion of parathyroid hormone‐related protein by human bone‐derived cells in vitro: Effects of glucocorticoids
- C. A. Walsh, M. Birch, +6 authors J. Gallagher
- Biology, Medicine
- Journal of bone and mineral research : the…
- 1 January 1995
We investigated the production of parathyroid hormone‐related protein (PTHrP) by cells derived from explants of human bone. Using an immunoradiometric assay (IRMA), PTHrP was detected in conditioned… Expand
Osteoblast-derived acetylcholinesterase: a novel mediator of cell-matrix interactions in bone?
- P. Genever, M. Birch, E. Brown, T. Skerry
- Biology, Medicine
- Bone
- 1 April 1999
The adhesive interactions that occur between bone cells and the developing matrix during bone formation help guide coupled remodeling and the maintenance of bone mass. Here, we provide evidence that… Expand
Absence of paramyxovirus RNA in cultures of pagetic bone cells and in pagetic bon
- M. Birch, W. Taylor, W. Fraser, S. Ralston, C. Hart, J. Gallagher
- Biology, Medicine
- Journal of bone and mineral research : the…
- 1 January 1994
It has been proposed that Paget's disease of bone is caused by the infection of bone cells with one or several paramyxoviruses. In this study we used the polymerase chain reaction (PCR), which allows… Expand