M. Bickel

Publications133
h-index31
Citations2,461
Highly Influential Citations43
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History of Drug Metabolism: Discoveries of the Major Pathways in the 19th Century
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The pharmacology and biochemistry of N-oxides.
  • M. Bickel
  • Chemistry, Biology
    Pharmacological reviews
  • 1 December 1969
TLDR
N-oxides are oxidation products of tertiary amines and were detected as a new class of chemical compounds before 1900 and were later found to occur as constituents of living matter and have been postulated as inducers of spontaneous cancer.
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Prediction of drug distribution in distribution dialysis and in vivo from binding to tissues and blood.
TLDR
The correlation between distribution in vitro (or calculated from binding values) and distribution in vivo, on the basis of literature data, indicated a reasonable agreement for antipyrine and the acidic lipophilic drugs used, as well as for the basic lipophile drugs, with respect to the brain, muscle, and adipose tissue.
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The contribution of lysosomal trapping in the uptake of desipramine and chloroquine by different tissues.
TLDR
The extent of uptake of cationic amphiphilic drugs into tissue slices was tissue-specific, and the contribution of the two uptake mechanisms was strongly drug-dependent.
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Single-dose kinetics of tissue distribution, excretion and metabolism of amiodarone in rats.
TLDR
According to the time-integrated parameters of distribution, AM has a potential to accumulate in adipose tissue under chronic administration and DEA accumulation would be likely to occur in lean tissues, mainly in the lung.
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History of drug metabolism: the first half of the 20th century.
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Kinetics of distribution and elimination of DDE in rats.
TLDR
It is concluded that excretion is limited by the slow formation of polar metabolites of DDE, and tissue kinetics and storage are controlled by unchanged DDE.
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N-oxide formation and related reactions in drug metabolism.
  • M. Bickel
  • Chemistry, Biology
    Xenobiotica; the fate of foreign compounds in…
  • 1 July 1971
TLDR
It could be shown that tertiary amine dealkylation and N-oxidation are catalyzed by microsomal enzymes only, whereas N-oxide dealkYLation and reduction occur only in extra-microsomal compartments.
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Comparative adipose tissue kinetics of thiopental, DDE and 2,4,5,2',4',5'-hexachlorobiphenyl in the rat.
TLDR
The results indicate that adipose tissue storage of drugs and other xenobiotics cannot be explained as a simple partition phenomenon and may be determined by initial binding in other tissue, although DDE and 6-CB are much more lipophilic than thiopental.
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The use of 2,4,5,2',4',5'-hexachlorobiphenyl (6-CB) as an unmetabolizable lipophilic model compound.
TLDR
The use of 6-CB in studies with tissue preparations in vitro is providing insight into transport mechanisms of uptake and release, including the possibility of an almost quantitative transfer of the maternal body burden to the offspring via milk.
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