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The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part II.
TLDR
It is illustrated that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs.
LC and UV determination of flavonoids from Passiflora alata medicinal extracts and leaves.
TLDR
The LC developed method was shown to be appropriated for the qualitative and quantitative analyses and for differentiate species, suitable to be applied to commercial sample analysis.
Characterization and potential uses of Copaifera langsdorfii seeds and seed oil.
TLDR
The presence of coumarin and xyloglucan as major components of C. langsdorfii seeds denotes its potential for use in the cosmetic or pharmaceutical industries and its homogeneity, low degree of polymer contaminants and high intrinsic viscosity and molecular mass represent good potential as a thickening agent.
Sesquiterpene lactones from Vernonia scorpioides and their in vitro cytotoxicity.
TLDR
The results indicate that glaucolide 2 and hirsutinolide 4 are toxic to HeLa cells, and these compounds were genotoxic in vitro, a property that appears to be related to the presence of their epoxy groups, which has been a more reliable indication of toxicity than substitution on C-13 or the existence of alpha,beta-unsaturated keto-groups.
Preliminary studies on Campomanesia xanthocarpa (Berg.) and Cuphea carthagenensis (Jacq.) J.F. Macbr. aqueous extract: weight control and biochemical parameters.
TLDR
Investigation in rats fed on a high calorie diet of Campomanesia xanthocarpa Berg and Guabiroba leaves and the herb Cuphea carthagenensis induced a significant reduction in weight gain in the rats, compared to the control group.
Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity
TLDR
The isolated chromenes 1 and 3 show a moderate leishmanicidal activity, and the isolated compounds are here reported for the first time in C. pinnatifida.
Phytochemical and Pharmacognostic Investigation of Bauhinia forficata Link (Leguminosae)
TLDR
Two phytoconstituents present in the B. forficata leaves, a medicinal plant employed in folk medicine specially for the treatment of diabetes, are isolated and it is indicated that the latter is present only in the leaves, suggesting that it might be useful for a suitable quality control of phytotherapeutics which contain this organ of the plant.
Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide
TLDR
This review focuses on SL antitumor activity related to cell-cycle arrest, differentiation, apoptosis induction through the intrinsic pathway, and sensitization of the extrinsic pathway and the regression of tumors in response to cotreatment with conventional chemotherapeutics.
LC characterisation of guaco medicinal extracts, Mikania laevigata and M. glomerata, and their effects on allergic pneumonitis.
TLDR
An LC method for the quantification of coumarin and O-coumaric acid in medicinal extracts was developed and validated for linearity, limit of detection, accuracy, precision, as well as intra- and inter-day variations.
Synergy: an old wisdom, a new paradigm for pharmacotherapy
TLDR
Through recent synergy studies, various synergistic interactions have been demonstrated among extracts of different plants, and between components of the same extract.
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