• Publications
  • Influence
DAMPs, PAMPs and alarmins: all we need to know about danger
  • M. Bianchi
  • Biology, Medicine
  • Journal of leukocyte biology
  • 1 January 2007
Multicellular animals detect pathogens via a set of receptors that recognize pathogen‐associated molecular patterns (PAMPs). However, pathogens are not the only causative agents of tissue and cellExpand
  • 2,313
  • 114
  • PDF
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes proteinExpand
  • 2,403
  • 98
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
This corrects the article DOI: 10.1038/nature00858
  • 1,074
  • 89
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
High Mobility Group 1 protein (HMGB1) is a chromatin component that, when leaked out by necrotic cells, triggers inflammation. HMGB1 can also be secreted by activated monocytes and macrophages, andExpand
  • 1,046
  • 74
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
Brain inflammation is a major factor in epilepsy, but the impact of specific inflammatory mediators on neuronal excitability is incompletely understood. Using models of acute and chronic seizures inExpand
  • 608
  • 49
Endogenous HMGB1 regulates autophagy
HMGB1 displaces Bcl-2 from Beclin1 to induce and sustain autophagy in response to cell stress.
  • 621
  • 42
  • PDF
The nuclear protein HMGB1 is secreted by monocytes via a non‐classical, vesicle‐mediated secretory pathway
HMGB1, a non‐histone nuclear factor, acts extracellularly as a mediator of delayed endotoxin lethality, which raises the question of how a nuclear protein can reach the extracellular space. We showExpand
  • 827
  • 41
  • PDF
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.
CpG-DNA or its synthetic analog CpG-ODN activates innate immunity through Toll-like receptor 9 (TLR9). However, the mechanism of TLR9 activation by CpG-DNA remains elusive. Here we have identifiedExpand
  • 427
  • 41
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
The activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities and is mediated by the transmembrane Toll-like receptors (TLRs) and cytosolicExpand
  • 549
  • 39
HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
CXCL12 forms a complex with HMGB1 that binds to the chemokine receptor CXCR4 and increases inflammatory cell migration.
  • 418
  • 37
  • PDF