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Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors.
Neurotrophins, such as neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF), are potent regulators of neuronal functions. Here we show that human immune cells also produce NT-3 mRNA,Expand
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Inhibition of Human Tumor-Infiltrating Lymphocyte Effector Functions by the Homophilic Carcinoembryonic Cell Adhesion Molecule 1 Interactions1
Efficient antitumor immune response requires the coordinated function of integrated immune components, but is finally exerted by the differentiated effector tumor-infiltrating lymphocytes (TIL). TILExpand
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Adoptive cell therapy with autologous tumor-infiltrating lymphocytes and high-dose interleukin-2 for metastatic melanoma: The surgeon's perspective.
Tumor-infiltrating lymphocytes (TILs) are produced by resecting tumor tissue and growing and expanding ex vivo large quantities of autologous T cells. Once the TILs are ready for infusion, theExpand
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CAR T cells induce a complete response in refractory Burkitt Lymphoma
We describe a 32-year-old male who presented with lymphadenopathy in December 2016. Morphology and immunohistochemistry from a lymph node biopsy were compatible with Burkitt Lymphoma (BL).Expand
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Normal human CD4+ helper T cells express Kv1.1 voltage-gated K+ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB
TNFα is a very potent and pleiotropic pro-inflammatory cytokine, essential to the immune system for eradicating cancer and microorganisms, and to the nervous system, for brain development and ongoingExpand
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Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy
In ENU induced rat glioma model, the location of tumor is unpredictable and serial observation of neoplastic changes in a single lesion is not possible. We induced neoplastic transformation ofExpand
Acknowledgement to Referees
In this the final issue of BioDrugs for 2014, the editors and production staff at Adis would like to take the opportunity to look back on all that has been achieved in the last 12 months and to thankExpand