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Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors.
Neurotrophins, such as neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF), are potent regulators of neuronal functions. Here we show that human immune cells also produce NT-3 mRNA,… Expand
Inhibition of Human Tumor-Infiltrating Lymphocyte Effector Functions by the Homophilic Carcinoembryonic Cell Adhesion Molecule 1 Interactions1
- G. Markel, R. Seidman, +10 authors J. Schachter
- Medicine, Biology
- The Journal of Immunology
- 1 November 2006
Efficient antitumor immune response requires the coordinated function of integrated immune components, but is finally exerted by the differentiated effector tumor-infiltrating lymphocytes (TIL). TIL… Expand
Receptors Th 1 / Th 2-Polarized Expression of Their mRNA by Human Immune Cells and Neurotrophic Factor and Neurotrophin-3 of the Neurotrophins Brain-Derived Cutting Edge : Clonally Restricted…
Adoptive cell therapy with autologous tumor-infiltrating lymphocytes and high-dose interleukin-2 for metastatic melanoma: The surgeon's perspective.
Tumor-infiltrating lymphocytes (TILs) are produced by resecting tumor tissue and growing and expanding ex vivo large quantities of autologous T cells. Once the TILs are ready for infusion, the… Expand
CAR T cells induce a complete response in refractory Burkitt Lymphoma
We describe a 32-year-old male who presented with lymphadenopathy in December 2016. Morphology and immunohistochemistry from a lymph node biopsy were compatible with Burkitt Lymphoma (BL).… Expand
Normal human CD4+ helper T cells express Kv1.1 voltage-gated K+ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB…
- Barbara Fellerhoff-Losch, S. V. Korol, +9 authors M. Levite
- Biology, Medicine
- Journal of Neural Transmission
- 1 March 2016
TNFα is a very potent and pleiotropic pro-inflammatory cytokine, essential to the immune system for eradicating cancer and microorganisms, and to the nervous system, for brain development and ongoing… Expand
Molecule 1 Interactions Homophilic Carcinoembryonic Cell Adhesion Lymphocyte Effector Functions by the Inhibition of Human Tumor-Infiltrating
Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy
In ENU induced rat glioma model, the location of tumor is unpredictable and serial observation of neoplastic changes in a single lesion is not possible. We induced neoplastic transformation of… Expand