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Genome sequence of the human malaria parasite Plasmodium falciparum
TLDR
The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria. Expand
ACT: the Artemis comparison tool
TLDR
The Artemis Comparison Tool (ACT) allows an interactive visualisation of comparisons between complete genome sequences and associated annotations and so inherits powerful searching and analysis tools. Expand
TriTrypDB: a functional genomic resource for the Trypanosomatidae
TLDR
TriTrypDB is an integrated database providing access to genome-scale datasets for kinetoplastid parasites, and supporting a variety of complex queries driven by research and development needs, utilizing a sophisticated search strategy system. Expand
The Genome of the African Trypanosome Trypanosoma brucei
TLDR
Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences. Expand
The genome of the social amoeba Dictyostelium discoideum
TLDR
A proteome-based phylogeny shows that the amoebozoa diverged from the animal–fungal lineage after the plant–animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi. Expand
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
TLDR
The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. Expand
The Genome of the Kinetoplastid Parasite, Leishmania major
TLDR
The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Tritryp genomes suggest that the mechanisms regulating RNA polymerase II–directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Expand
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
TLDR
There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence in Candida albicans species. Expand
REAPR: a universal tool for genome assembly evaluation
TLDR
This work validated REAPR on complete genomes or de novo assemblies from bacteria, malaria and Caenorhabditis elegans, and demonstrated that 86% and 82% of the human and mouse reference genomes are error-free, respectively. Expand
Artemis: an integrated platform for visualization and analysis of high-throughput sequence-based experimental data
TLDR
Artemis is presented as a tool for integrated visualization and computational analysis of different types of HTS datasets in the context of a reference genome and its corresponding annotation. Expand
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