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Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens.
Human brain tumors appear to have a hierarchical cellular organization suggestive of a stem cell foundation. In vitro expansion of the putative cancer stem cells as stable cell lines would provide aExpand
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Neurological manifestations of intracranial dural arteriovenous malformations.
The authors describe their experience with four cases of dural arteriovenous malformation (AVM) which led them to analyze the clinical aspects of these lesions in an attempt to understand theirExpand
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Patterns of hypertext
The apparent unruliness of contemporary hypertexts arises, in part, from our lack of a vocabulary to describe hypertext structures. Expand
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Card shark and thespis: exotic tools for hypertext narrative
Card Shark and Thespis are two newly-implemented hypertext systems for creating hypertext narrative. Expand
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Awake craniotomy with brain mapping as the routine surgical approach to treating patients with supratentorial intraaxial tumors: a prospective trial of 200 cases.
OBJECT Awake craniotomy was performed as the standard surgical approach to supratentorial intraaxial tumors, regardless of the involvement of eloquent cortex, in a prospective trial of 200 patientsExpand
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Prospective study of awake craniotomy used routinely and nonselectively for supratentorial tumors.
OBJECT The authors prospectively assessed the value of awake craniotomy used nonselectively in patients undergoing resection of supratentorial tumors. METHODS The demographic features, presentingExpand
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Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals on GBM growth is largely unexplored. We interrogated 680 neurochemical compounds in patient-derived GBMExpand
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Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity
Significance Glioblastoma is an incurable brain tumor. It is characterized by intratumoral phenotypic and genetic heterogeneity, but the functional significance of this heterogeneity is unclear. WeExpand
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Thalamic tumors in children. Long-term follow-up and treatment guidelines.
The authors review the cases of 60 children (aged 5 months to 18 years) with thalamic tumors who were seen at The Hospital for Sick Children between 1951 and 1983. The diagnosis of thalamic tumor wasExpand
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Delays in the operating room: signs of an imperfect system.
BACKGROUND Delays in the operating room have a negative effect on its efficiency and the working environment. In this prospective study, we analyzed data on perioperative system delays. METHODS OneExpand
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