• Publications
  • Influence
Preferential recruitment of interferon‐γ–expressing TH17 cells in multiple sclerosis
There is substantial evidence supporting the role of interferon (IFN)‐γ–producing T helper (TH) 1 and interleukin (IL)‐17–expressing TH17 lymphocytes in multiple sclerosis (MS) and its animal model,Expand
  • 415
  • 27
Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis
The blood–brain barrier (BBB) restricts molecular and cellular trafficking between the blood and the CNS. Although astrocytes are known to control BBB permeability, the molecular determinants of thisExpand
  • 187
  • 7
  • PDF
Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat
Objective:To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolicExpand
  • 72
  • 7
Statins reduce human blood–brain barrier permeability and restrict leukocyte migration: Relevance to multiple sclerosis
Dysregulation of the blood–brain barrier (BBB) and transendothelial migration of immune cells are among the earliest central nervous system changes partaking in lesion formation in both multipleExpand
  • 141
  • 5
Novel Fibrogenic Pathways Are Activated in Response to Endothelial Apoptosis: Implications in the Pathophysiology of Systemic Sclerosis1
Apoptosis of endothelial cells (EC) is appreciated as a primary pathogenic event in systemic sclerosis. Yet, how apoptosis of EC leads to fibrosis remains to be determined. We report that apoptosisExpand
  • 105
  • 5
Myocardial blood flow mapping in mice using high‐resolution spin labeling magnetic resonance imaging: Influence of ketamine/xylazine and isoflurane anesthesia
Genetically modified mouse models of many human diseases reflecting cardiovascular alterations are currently available. To date, little information on absolute myocardial perfusion in mice is foundExpand
  • 107
  • 4
Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: a prospective randomized clinical trial using magnetic resonance imaging and
To conduct a prospective randomized trial to investigate the effect of glucagon‐like peptide‐1 (GLP‐1) analogues on ectopic fat stores.
  • 73
  • 4
Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF
Recent evidence suggests that autophagy may favor fibrosis through enhanced differentiation of fibroblasts in myofibroblasts. Here, we sought to characterize the mediators and signaling pathwaysExpand
  • 44
  • 3
Intracellular pH and role of Na+/H+ exchange during ischaemia and reperfusion of normal and diabetic rat hearts.
STUDY OBJECTIVE The aim was to investigate the role of intracellular pH (pHi) and ion exchange on the functional recovery of perfused hearts isolated from normal (N) rats either receiving or notExpand
  • 97
  • 2
The blood–brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells
Trafficking of antigen-presenting cells into the CNS is essential for lymphocyte reactivation within the CNS compartment. Although perivascular dendritic cells found in inflammatory lesions areExpand
  • 105
  • 2