• Publications
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Byonic: Advanced Peptide and Protein Identification Software
Byonic is the name of a software package for peptide and protein identification by tandem mass spectrometry. Expand
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Automatic particle selection: results of a comparative study.
Manual selection of single particles in images acquired using cryo-electron microscopy (cryoEM) will become a significant bottleneck when datasets of a hundred thousand or even a million particlesExpand
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Automated N-glycopeptide identification using a combination of single- and tandem-MS.
We describe Peptoonist, a program that can automatically identify the glycans (sugars) present at each N-glycosylation site of a protein. The input to Peptoonist is a series of mass spectra, both MSExpand
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Glycoproteomic Analysis of the Secretome of Human Endothelial Cells*
Previous proteomics studies have partially unraveled the complexity of endothelial protein secretion but have not investigated glycosylation, a key modification of secreted and membrane proteins forExpand
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Molecular analyses of dinosaur osteocytes support the presence of endogenous molecules.
The discovery of soft, transparent microstructures in dinosaur bone consistent in morphology with osteocytes was controversial. We hypothesize that, if original, these microstructures will haveExpand
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A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ
Significance A biochemically unique cone snail venom peptide has been characterized that may be used to probe unexplored but important features of the diverse voltage-gated Na channel isoforms thatExpand
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Preview: a program for surveying shotgun proteomics tandem mass spectrometry data.
Database search programs for peptide identification by tandem mass spectrometry ask their users to set various parameters, including precursor and fragment mass tolerances, digestion specificity, andExpand
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Elucidating in Vivo Structural Dynamics in Integral Membrane Protein by Hydroxyl Radical Footprinting*
We describe here a novel footprinting technique to probe the in vivo structural dynamics of membrane protein. This method utilized in situ generation of hydroxyl radicals to oxidize and covalentlyExpand
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Toward Automated N-Glycopeptide Identification in Glycoproteomics.
Advances in software-driven glycopeptide identification have facilitated N-glycoproteomics studies reporting thousands of intact N-glycopeptides, i.e., N-glycan-conjugated peptides, but the automatedExpand
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Extended O-GlcNAc on HLA Class-I-Bound Peptides.
We report unexpected mass spectrometric observations of glycosylated human leukocyte antigen (HLA) class I-bound peptides. Complemented by molecular modeling, in vitro enzymatic assays, and oxoniumExpand
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