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A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness
TLDR
It is concluded that aberrations in O&NS pathways are--together with the inflammatory processes--key components of depression, and the results suggest that depression belongs to the spectrum of (neuro)degenerative disorders. Expand
Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors
TLDR
Emerging data shows that these biomarkers may differ between early and late stages of BD in parallel with stage-related structural and neurocognitive alterations, which facilitates identification of rational therapeutic targets, and the development of novel treatment classes. Expand
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar
The Canadian Network for Mood and Anxiety Treatments published guidelines for the management of bipolar disorder in 2005, with updates in 2007 and 2009. This third update, in conjunction with theExpand
The chemistry and biological activities of N-acetylcysteine.
TLDR
The present review is focused on the chemistry of NAC and its interactions and functions at the organ, tissue and cellular levels in an attempt to bridge the gap between its recognized biological activities and chemistry. Expand
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar
The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update. This second update, in conjunction with theExpand
The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications
TLDR
Current knowledge of the neuroprogressive processes that may occur in MDD is reviewed, including structural brain consequences and potential molecular mechanisms including the role of neurotransmitter systems, inflammatory, oxidative and nitrosative stress pathways, neurotrophins and regulation of neurogenesis, cortisol and the hypothalamic–pituitary–adrenal axis modulation. Expand
The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders.
TLDR
A consensus was reached on 12 statements on the use of antidepressants in bipolar disorder, and antidepressants should be prescribed only as an adjunct to mood-stabilizing medications. Expand
Validation of the Edinburgh Postnatal Depression Scale on a cohort of South African women.
TLDR
The EPDS, administered verbally, is a valid screening instrument in this urban South African community and validated against the Diagnostic and Statistical Manual (DSM-IV) criteria for depression. Expand
So depression is an inflammatory disease, but where does the inflammation come from?
TLDR
The identification of known sources of inflammation provides support for inflammation as a mediating pathway to both risk and neuroprogression in depression. Expand
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