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Cost of migration: invasion of malignant gliomas and implications for treatment.
Tumors of glial origin consist of a core mass and a penumbra of invasive, single cells, decreasing in numbers towards the periphery and still detectable several centimeters away from the core lesion.Expand
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Molecular targets of glioma invasion
Abstract.Glioblastoma multiforme is the most common and lethal primary malignant brain tumor. Although considerable progress has been made in technical proficiencies of surgical and radiationExpand
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Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment.
Invasion is a defining hallmark of glioblastoma multiforme, just as metastasis characterizes other high-grade tumors. Glial tumors invariably recur due to the regrowth of invasive cells, which areExpand
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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying theExpand
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Molecular Mechanisms of Glioma Cell Migration and Invasion
Gliomas are the most common intracranial tumors. In the US, approximately 15,000 patients die with glioblastoma per year (CBTRUS 2002). Despite modern diagnostics and treatments the median survivalExpand
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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in humanExpand
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A mathematical model of glioblastoma tumor spheroid invasion in a three-dimensional in vitro experiment.
Glioblastoma, the most malignant form of brain cancer, is responsible for 23% of primary brain tumors and has extremely poor outcome. Confounding the clinical management of glioblastomas is theExpand
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Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3.
Therapies targeting glioma cells that diffusely infiltrate normal brain are highly sought after. Our aim was to identify novel approaches to this problem using glioma spheroid migration assays.Expand
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The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.
Malignant gliomas are characterized by their ability to invade normal brain tissue. We have previously shown that the small GTPase Rac1 plays a role in both migration and invasion in gliomas. Here,Expand
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Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression
Glioblastoma (GB) is the most malignant of primary adult brain tumors, characterized by a highly locally invasive cell population, as well as abundant proliferative cells, neoangiogenesis, andExpand
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