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Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models
PARN, poly(A)‐specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the hTR RNA component of telomerase. Biallelic PARN mutations were associated withExpand
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NHP2 deficiency impairs rRNA biogenesis and causes pulmonary fibrosis and Høyeraal-Hreidarsson syndrome.
Telomeres are nucleoprotein structures at the end of chromosomes. The telomerase complex, constituted of the catalytic subunit TERT, the RNA matrix hTR, and several cofactors including the H/ACA boxExpand
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Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models
PARN, poly(A)-specific ribonuclease, regulates the turnover of mRNAs and the maturation and stabilization of the hTR RNA component of telomerase. Biallelic PARN mutations were associated withExpand
Le rôle de l'oncoprotéine INT6 dans la maintenance des télomères
La proteine INT6/EIF3E codee par le gene mammalien correspondant au site d’integration du retrovirus Mouse Mammary tumor virus (MMTV) n°6 (int-6), a ete impliquee dans le cancer du sein chez laExpand