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  • Influence
A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis
Recent clinical studies reveal that selective agonists of group II metabotropic glutamate (mGlu) receptors have robust efficacy in treating positive and negative symptoms in patients withExpand
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Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior
A subset of glutamate receptors that are specifically sensitive to the glutamate analog N-methyl-Daspartate (NMDA) are molecular coincidence detectors, necessary for activity-dependent processes ofExpand
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Cell Selective Conditional Null Mutations of Serine Racemase Demonstrate a Predominate Localization in Cortical Glutamatergic Neurons
Abstractd-Serine, which is synthesized by the enzyme serine racemase (SR), is a co-agonist at the N-methyl-d-aspartate receptor (NMDAR). Crucial to an understanding of the signaling functions ofExpand
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Mechanisms underlying the activation of G-protein–gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297
Significance Many neurotransmitters dampen excitability in the heart and brain by activating G-protein–gated inwardly rectifying K+ (GIRK) channels. The lack of selective pharmacological tools forExpand
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Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior
A subset of glutamate receptors that are specifically sensitive to the glutamate analog N-methyl-D-aspartate (NMDA) are molecular coincidence detectors, necessary for activity-dependent processes ofExpand
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Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction
  • D. Balu, Y. Li, +5 authors J. Coyle
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 31 May 2013
Significance We sought to determine whether the diverse hippocampal neuropathology observed in schizophrenia could be recapitulated in an animal model of NMDA receptor (NMDAR) hypofunction. SerineExpand
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Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.
Schizophrenia affects approximately 1% of the population and continues to be associated with poor outcome because of the limited efficacy of and noncompliance with existing antipsychotic medications.Expand
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d-Serine and Serine Racemase are Localized to Neurons in the Adult Mouse and Human Forebrain
Abstractd-Serine, a co-agonist at the NMDA receptor (NMDAR), is synthesized from l-serine by the enzyme serine racemase (SR), which is heavily expressed in the forebrain. Although SR was originallyExpand
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Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice
RationaleThe drug discrimination procedure is the most frequently used in vivo model of hallucinogen activity. Historically, most drug discrimination studies have been conducted in the rat. With theExpand
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Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers
Reduction in cortical presynaptic markers, notably parvalbumin (PV), for the chandelier subtype of inhibitory γ-amino-butyric acid (GABA) interneurons is a highly replicated post-mortem finding inExpand
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