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A Review of the Neural Mechanisms of Action and Clinical Efficiency of Riluzole in Treating Amyotrophic Lateral Sclerosis: What have we Learned in the Last Decade?
  • M. Bellingham
  • Biology
    CNS neuroscience & therapeutics
  • 1 February 2011
TLDR
In animals, in vivo administration of riluzole produced relatively minor effects on normal respiration parameters, but inhibited hypoxia‐induced gasping, which may have implications for the management of hypoventilation and sleep‐disordered breathing during end‐stage ALS in humans.
Characteristics and postnatal development of a hyperpolarization-activated inward current in rat hypoglossal motoneurons in vitro.
TLDR
There was a marked increase in the amplitude of Ih during postnatal development of HMs, and results suggest that the increased amplitude ofIh results from an increase in Ih current density.
Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis
TLDR
These findings underscore the widespread and early onset of abnormal neural activity in this mouse model of the adult neurodegenerative disease ALS, and suggest that suppression of PCNa and hyperexcitability early in life might be one way to mitigate or prevent cell death in the adult CNS.
Developmental changes in EPSC quantal size and quantal content at a central glutamatergic synapse in rat
TLDR
These data are consistent with a developmentally increased efficacy of AMPA receptor‐mediated synaptic transmission at the endbulb‐bushy cell synapse, due to an increase in underlying AMPA‐mediated quantal size and content during the same period as a transient co‐localization of NMDA receptors.
A method for the three-dimensional reconstruction of Neurobiotin™-filled neurons and the location of their synaptic inputs
TLDR
A robust method for mapping the number and type of neuro-chemically distinct synaptic inputs that a single reconstructed neuron receives and can be adapted to super-resolution microscopy techniques, which will enhance its applicability to the study of neural circuits at the level of synapses.
Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
TLDR
These findings demonstrate extensive early changes in motor cortex of the SOD1 mouse model, which thus recapitulates clinically relevant cortical pathophysiology more faithfully than previously thought.
Adenosinergic modulation of respiratory neurones and hypoxic responses in the anaesthetized cat.
TLDR
The modulatory effects of intracellularly injected adenosine on membrane potential, input resistance and spontaneous or evoked synaptic activity were determined in respiratory neurones of the ventral respiratory group, indicating thatAdenosine A1 receptors are tonically activated under control conditions.
Presynaptic inhibition of glutamatergic synaptic transmission to rat motoneurons by serotonin.
TLDR
It is concluded that 5- HT, acting through presynaptic 5-HT1B receptors, inhibits glutamatergic synaptic transmission by reducing the probability of vesicle release.
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