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Small-molecule WNK inhibition regulates cardiovascular and renal function.
- Ken Yamada, Hyi-Man Park, L. Monovich
- Biology, ChemistryNature chemical biology
- 1 November 2016
TLDR
Pharmacodynamic and Pharmacokinetic Characterization of the Aldosterone Synthase Inhibitor FAD286 in Two Rodent Models of Hyperaldosteronism: Comparison with the 11β-Hydroxylase Inhibitor Metyrapone
- D. Rigel, F. Fu, M. Beil, Chii-Whei Hu, Guiqing Liang, A. Jeng
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 July 2010
TLDR
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
- E. Meredith, G. Ksander, D. Lasala
- Biology, MedicineACS medicinal chemistry letters
- 17 October 2013
TLDR
Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling
- N. Snelder, B. Ploeger, M. Danhof
- BiologyBritish journal of pharmacology
- 1 November 2014
TLDR
PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats
- N. Snelder, B. Ploeger, M. Danhof
- BiologyBritish journal of pharmacology
- 1 August 2013
TLDR
Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects
TLDR
Design and synthesis of a potent and selective endothelin-converting enzyme inhibitor, CGS 35066.
- A. Jeng, S. De Lombaert, A. Trapani
- Biology, ChemistryJournal of cardiovascular pharmacology
- 2000
TLDR
CGS 35601 and its Orally Active Prodrug CGS 37808 as Triple Inhibitors of Endothelin-converting Enzyme-1, Neutral Endopeptidase 24.11, and Angiotensin-converting Enzyme
- A. Trapani, M. Beil, C. Bruseo, P. Savage, F. Firooznia, A. Jeng
- Biology, MedicineJournal of cardiovascular pharmacology
- 1 November 2004
TLDR
Evaluation of the cardiovascular effects of arecoline in the anesthetized dog
- M. Beil, F. R. Goodman, H. Shlevin, E. F. Smith
- Chemistry, Biology
- 1 November 1986
TLDR
Age and muscle-type modulated role of intramyocellular lipids in the progression of insulin resistance in nondiabetic Zucker rats.
- M. Korach-André, J. Gounarides, D. Laurent
- BiologyMetabolism: clinical and experimental
- 1 April 2005
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