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Global Epigenomic Reconfiguration During Mammalian Brain Development
The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits.
Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases
- B. Viviani, S. Bartesaghi, M. Marinovich
- Biology, ChemistryThe Journal of Neuroscience
- 24 September 2003
The data suggest that IL-1β increases NMDA receptor function through activation of tyrosine kinases and subsequent NR2A/B subunit phosphorylation, which may contribute to glutamate-mediated neurodegeneration.
Ketamine-Induced Loss of Phenotype of Fast-Spiking Interneurons Is Mediated by NADPH-Oxidase
It is shown that exposure of mice to ketamine induced a persistent increase in brain superoxide due to activation in neurons of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which suggests that NADPH oxidase may represent a novel target for the treatment of ketamine-induced psychosis.
Zinc-Induced Cortical Neuronal Death: Contribution of Energy Failure Attributable to Loss of NAD+ and Inhibition of Glycolysis
Zn2+-induced neuronal death was attenuated by addition of the energy substrate oxaloacetate, the activator of pyruvate dehydrogenase, dichloroacetates, or the inhibitors of NAD+ catabolism, niacinamide or benzamide, and the neuroprotective effects of pyrupvate addition were associated with normalization of cellular levels of NAD+, DHAP, and FBP.
Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex
A comprehensive map of methylation variation in neuronal cell populations, including a between-species comparison, illustrates how epigenetic diversity plays important roles in neuronal development.
A Loss of Parvalbumin-Containing Interneurons Is Associated with Diminished Oscillatory Activity in an Animal Model of Schizophrenia
It is proposed that a decrease in intrinsic GABAergic signaling may be responsible, at least in part, for the prefrontal and hippocampal hypofunctionality observed during task performance, which is consistently observed in animal models as well as in schizophrenia in humans.
Interleukin‐1β contributes to the generation of experimental febrile seizures
- C. Dubé, A. Vezzani, M. Behrens, T. Bártfai, T. Baram
- Biology, MedicineAnnals of neurology
- 1 January 2005
It is indicated that IL‐1β signaling contributes critically to fever‐induced hyperexcitability underlying FS, constituting a potential target for their prevention.
A Specific Role for NR2A-Containing NMDA Receptors in the Maintenance of Parvalbumin and GAD67 Immunoreactivity in Cultured Interneurons
- J. Kinney, Christopher N. Davis, I. Tabarean, B. Conti, T. Bártfai, M. Behrens
- BiologyThe Journal of Neuroscience
The results suggest that the activity of NR2A-containing NMDA receptors play a pivotal role in the maintenance of the GABAergic function of PV interneurons.
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
- X. Lu, A. Barr, T. Bártfai
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 18 January 2005
It is demonstrated that 14 days of FLX treatment up-regulated galanin mRNA levels by 100% and GalR2-binding sites by 50%, in the rat dorsal raphe nucleus, where galAnin coexists with serotonin, underlining the connection between activation of the galan inergic system and antidepressant action of various clinically proven treatments.
Metabotropic Glutamate Receptor 1-Induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-Family Kinase Pathway in Cortical Neurons
In cortical neurons, brief selective activation of group I mGluRs with (S)-3,5-dihydroxy-phenylglycine with DHPG induced a Ca2+–calmodulin-dependent activation of Pyk2/CAKβ and the Src-family kinases Src and Fyn that was independent of protein kinase C (PKC).