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Origin of slow cortical oscillations in deafferented cortical slabs.
- I. Timofeev, F. Grenier, M. Bazhenov, T. Sejnowski, M. Steriade
- BiologyCerebral cortex
- 1 December 2000
An in vivo preparation has been developed to study the mechanisms underlying spontaneous sleep oscillations in anesthetized cats and an analytical model of the cortical network accurately predicted the scaling observed in simulations and from recordings in cortical slabs of increasing size.
Model of Thalamocortical Slow-Wave Sleep Oscillations and Transitions to Activated States
The model describes many essential features of SWS and activated states in the thalamocortical system as well as the transition between them, and the input resistance of cortical neurons gradually increased and, in a fully activated state, reached the same or even higher values as during silent phases ofSWS oscillations.
Olfactory representations by Drosophila mushroom body neurons.
By comparing activity patterns evoked by the same odors across olfactory receptor neurons and across KCs, it is shown that representations of different odors do indeed become less correlated as they progress through the o aroma system.
Corticothalamic Feedback Controls Sleep Spindle Duration In Vivo
- M. Bonjean, Tanya I. Baker, Maxime Lemieux, I. Timofeev, T. Sejnowski, M. Bazhenov
- BiologyThe Journal of Neuroscience
- 22 June 2011
It is found that although the propagation of spindles depended on synaptic interaction within the thalamus, the initiation and termination of spindle sequences critically involved corticothalamic influences.
Ionic Dynamics Mediate Spontaneous Termination of Seizures and Postictal Depression State
Using a realistic computational model, it is demonstrated that termination of seizure and postictal depression state may be mediated by dynamics of the intracellular and extracellular ion concentrations.
Model of Cellular and Network Mechanisms for Odor-Evoked Temporal Patterning in the Locust Antennal Lobe
Potassium Dynamics in the Epileptic Cortex: New Insights on an Old Topic
- F. Fröhlich, M. Bazhenov, V. Iragui-Madoz, T. Sejnowski
- BiologyThe Neuroscientist : a review journal bringing…
- 1 October 2008
classical and more recent insights on [K+] o dynamics in the cortex are connected with the goal of providing starting points for a next generation of [K+.o research, which may ultimately lead to an entirely new class of antiepileptic drugs that act on the [K+)o regulation system.
Homeostatic synaptic plasticity can explain post-traumatic epileptogenesis in chronically isolated neocortex.
- A. R. Houweling, M. Bazhenov, I. Timofeev, M. Steriade, T. Sejnowski
- BiologyCerebral cortex
- 1 June 2005
A role for homeostatic synaptic plasticity as a novel mechanism of post-traumatic epileptogenesis is supported by computer models of neocortex incorporating a biologically basedHomeostatic plasticity rule that operates to maintain firing rates.
Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans
It is found that systemic administration of the GABAergic drug (zolpidem) increased both the phase-amplitude coupling between SO and spindles, and verbal memory improvement in humans, suggesting that thalamic spindled transitions that occur during transitions to the cortical SO Up state are optimal for memory consolidation.
Computational Models of Thalamocortical Augmenting Responses
Intracortical inhibition had an important influence on the genesis of augmenting responses in cortical neurons: A shift in the balance between intracortical excitation and inhibition toward excitation transformed an augmenting response to long-lasting paroxysmal discharge.