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Origin of slow cortical oscillations in deafferented cortical slabs.
An in vivo preparation has been developed to study the mechanisms underlying spontaneous sleep oscillations in anesthetized cats and an analytical model of the cortical network accurately predicted the scaling observed in simulations and from recordings in cortical slabs of increasing size. Expand
Model of Thalamocortical Slow-Wave Sleep Oscillations and Transitions to Activated States
The model describes many essential features of SWS and activated states in the thalamocortical system as well as the transition between them, and the input resistance of cortical neurons gradually increased and, in a fully activated state, reached the same or even higher values as during silent phases ofSWS oscillations. Expand
Olfactory representations by Drosophila mushroom body neurons.
By comparing activity patterns evoked by the same odors across olfactory receptor neurons and across KCs, it is shown that representations of different odors do indeed become less correlated as they progress through the o aroma system. Expand
Ionic Dynamics Mediate Spontaneous Termination of Seizures and Postictal Depression State
Using a realistic computational model, it is demonstrated that termination of seizure and postictal depression state may be mediated by dynamics of the intracellular and extracellular ion concentrations. Expand
Homeostatic synaptic plasticity can explain post-traumatic epileptogenesis in chronically isolated neocortex.
A role for homeostatic synaptic plasticity as a novel mechanism of post-traumatic epileptogenesis is supported by computer models of neocortex incorporating a biologically basedHomeostatic plasticity rule that operates to maintain firing rates. Expand
Computational Models of Thalamocortical Augmenting Responses
Intracortical inhibition had an important influence on the genesis of augmenting responses in cortical neurons: A shift in the balance between intracortical excitation and inhibition toward excitation transformed an augmenting response to long-lasting paroxysmal discharge. Expand
Model of Transient Oscillatory Synchronization in the Locust Antennal Lobe
A Hodgkin-Huxley-type model of the AL shows how alternations of the inhibitory drive can temporally encode sensory information in networks of neurons without precisely tuned intrinsic oscillatory properties. Expand
Potassium Dynamics in the Epileptic Cortex: New Insights on an Old Topic
The role of changes in the extracellular potassium concentration [K+]o in epilepsy has remained unclear. Historically, it was hypothesized that [K+] o is the causal factor for epileptic seizures.Expand
Model of Cellular and Network Mechanisms for Odor-Evoked Temporal Patterning in the Locust Antennal Lobe
Fast and slow inhibitory mechanisms at synapses between LNs and PNs can form dynamical PN assemblies whose elements synchronize transiently and oscillate collectively, as observed not only in the locust AL, but also in the vertebrate olfactory bulb. Expand
Corticothalamic Feedback Controls Sleep Spindle Duration In Vivo
It is found that although the propagation of spindles depended on synaptic interaction within the thalamus, the initiation and termination of spindle sequences critically involved corticothalamic influences. Expand