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Characterization of an RTX toxin from enterohemorrhagic Escherichia coli O157:H7.
A hemolytic determinant of enterohemorrhagic Escherichia coli O157:H7 is encoded on a 90-kbp plasmid (pO157). This enterohemorrhagic E. coli toxin (Ehx) is a newly described RTX cytotoxin. TheExpand
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Immunopathogenesis of Haemophilus ducreyi Infection (Chancroid)
Haemophilus ducreyi causes chancroid, a genital ulcer disease (GUD) that is common in many developing countries ([13][1], [14][2], [26][3], [68][4], [80][5], [103][6]). UNAIDS and the World HealthExpand
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Haemophilus ducreyi Associates with Phagocytes, Collagen, and Fibrin and Remains Extracellular throughout Infection of Human Volunteers
ABSTRACT In a previous study, Haemophilus ducreyi was found in the pustule and dermis of samples obtained at the clinical end point in the human model of infection. To understand the kinetics ofExpand
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DNA activates human immune cells through a CpG sequence‐dependent manner
While bacterial DNA and cytosine–guanosine‐dinucleotide‐containing oligonucleotides (CpG ODN) are well described activators of murine immune cells, their effect on human cells is inconclusive. WeExpand
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Association of RTX toxins with erythrocytes.
A critical step in the target cell attack by RTX cytotoxins is their association with target cells. A binding assay was used to study the association of the Escherichia coli hemolysin protein (HlyA)Expand
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Pleiotropic effects of a mutation in rfaC on Escherichia coli hemolysin.
Several genes involved in the lipopolysaccharide (LPS) biosynthetic pathway have been shown to affect the expression or activity of Escherichia coli hemolysin (Hly), a secreted cytotoxin that is theExpand
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Haemophilus ducreyi SapA Contributes to Cathelicidin Resistance and Virulence in Humans
ABSTRACT Haemophilus ducreyi is an extracellular pathogen of human epithelial surfaces that resists human antimicrobial peptides (APs). The organism's genome contains homologs of genes sensitive toExpand
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A fibrinogen-binding lipoprotein contributes to the virulence of Haemophilus ducreyi in humans.
A gene expression study of Haemophilus ducreyi identified the hypothetical lipoprotein HD0192, renamed here "fibrinogen binder A" (FgbA), as being preferentially expressed in vivo. To test the roleExpand
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Identification of Haemophilus ducreyi genes expressed during human infection.
To identify Haemophilus ducreyi transcripts that are expressed during human infection, we used selective capture of transcribed sequences (SCOTS) with RNA isolated from pustules obtained from threeExpand
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Expression of Peptidoglycan-Associated Lipoprotein Is Required for Virulence in the Human Model of Haemophilus ducreyi Infection
ABSTRACT Haemophilus ducreyi expresses a peptidoglycan-associated lipoprotein (PAL) that exhibits extensive homology to Haemophilus influenzae protein 6. We constructed an isogenic PAL mutantExpand
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