• Publications
  • Influence
Endoplasmic reticulum stress and the development of endothelial dysfunction.
The vascular endothelium plays a critical role in cardiovascular homeostasis, and thus identifying the underlying causes of endothelial dysfunction has important clinical implications. In thisExpand
  • 33
  • 3
The gut microbiota as a novel regulator of cardiovascular function and disease.
The gut microbiome has emerged as a critical regulator of human physiology. Deleterious changes to the composition or number of gut bacteria, commonly referred to as gut dysbiosis, has been linked toExpand
  • 45
  • 2
Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice
Mitochondrial dysregulation and associated excessive reactive oxygen species (mtROS) production is a key source of oxidative stress in aging arteries that reduces baseline function and may influenceExpand
  • 17
  • 2
  • PDF
SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice
BackgroundType 2 diabetes (T2D) is associated with generalized vascular dysfunction characterized by increases in large artery stiffness, endothelial dysfunction, and vascular smooth muscleExpand
  • 42
  • 1
Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice
Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive dysfunction, and other chronic disorders of aging. Mitochondria-derived reactive oxygen species are a keyExpand
  • 34
  • 1
  • PDF
Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice
Age‐related arterial dysfunction, characterized by oxidative stress‐ and inflammation‐mediated endothelial dysfunction and arterial stiffening, is the primary risk factor for cardiovascular diseases.Expand
  • 19
  • 1
Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction.
Vascular dysfunction represents a critical preclinical step in the development of cardiovascular disease. We examined the role of the gut microbiota in the development of obesity-related vascularExpand
  • 20
  • 1
Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice.
Aging is associated with motor declines that lead to functional limitations and disability, necessitating the development of therapies to slow or reverse these events. We tested the hypothesis thatExpand
  • 16
  • 1
  • PDF
Tauroursodeoxycholic Acid Reduces Arterial Stiffness and Improves Endothelial Dysfunction in Type 2 Diabetic Mice
Background/Aims: Endoplasmic reticulum (ER) stress has emerged as a potential mechanism contributing to diabetes and its comorbidities. However, the importance of ER stress in diabetic vascularExpand
  • 13
Gut microbiota regulates cardiac ischemic tolerance and aortic stiffness in obesity.
The gut microbiota has emerged as an important regulator of host physiology, with recent data suggesting a role in modulating cardiovascular health. The present study determined if gut microbialExpand
  • 2