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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
The "BH3-only" proteins of the BCL-2 family require "multidomain" proapoptotic members BAX and BAK to release cytochrome c from mitochondria and kill cells. We find short peptides representing theExpand
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Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
While the catalog of mammalian transcripts and their expression levels in different cell types and disease states is rapidly expanding, our understanding of transcript function lags behind. WeExpand
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JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.
Starvation induces autophagy to preserve cellular homeostasis in virtually all eukaryotic organisms. However, the mechanisms by which starvation induces autophagy are not completely understood. InExpand
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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
Exercise has beneficial effects on human health, including protection against metabolic disorders such as diabetes. However, the cellular mechanisms underlying these effects are incompletelyExpand
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Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.
Proapoptotic BCL-2 family members BAX and BAK are required for the initiation of mitochondrial dysfunction during apoptosis and for maintaining the endoplasmic reticulum (ER) Ca(2+) stores necessaryExpand
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Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α
Accumulation of misfolded protein in the endoplasmic reticulum (ER) triggers an adaptive stress response—termed the unfolded protein response (UPR)—mediated by the ER transmembrane protein kinase andExpand
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A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility
Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the systematic exploration of gene function inExpand
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Phosphorylation of BCL‐2 regulates ER Ca2+ homeostasis and apoptosis
Phosphorylation of BCL‐2 within an unstructured loop inhibits its antiapoptotic effect. We found that phosphorylated BCL‐2 predominantly localized to the endoplasmic reticulum (ER) and tested whetherExpand
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Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators
Transposable elements, also known as transposons, are now recognized not only as parasitic DNA, the spread of which in the genome must be controlled by the host, but also as major players in genomeExpand
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Biochemical and Genetic Analysis of the Mitochondrial Response of Yeast to BAX and BCL-XL
ABSTRACT The BCL-2 family includes both proapoptotic (e.g., BAX and BAK) and antiapoptotic (e.g., BCL-2 and BCL-XL) molecules. The cell death-regulating activity of BCL-2 members appears to depend onExpand
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