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Alterations in membrane fluidity, lipid metabolism, mitochondrial activity, and lipophosphoglycan expression in pentamidine-resistant Leishmania
Abstract Cytoplasmic and mitochondrial membranes were studied in wild-type promastigotes of Leishmania donovani and L. amazonensis treated with pentamidine and in the parasites resistant to thisExpand
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Pentamidine uptake in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes.
A transport system for pentamidine in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes has been identified and characterized. Pentamidine is not metabolized byExpand
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Sinefungin shares AdoMet-uptake system to enter Leishmania donovani promastigotes.
The involvement of a carrier for sinefungin (SF) uptake in Leishmania donovani promastigotes is indicated by saturation kinetics, competition studies and SF accumulation against a 270-foldExpand
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Effects of pentamidine on polyamine level and biosynthesis in wild-type, pentamidine-treated, and pentamidine-resistant Leishmania.
Polyamine biosynthesis was studied in wild-type promastigotes of Leishmania donovani and Leishmania amazonensis treated with pentamidine and in the parasites resistant to this drug. Treatment ofExpand
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Pneumocystis carinti erg6 Gene: Sequencing and Expression of Recombinant SAM:Sterol Methyltransferase in Heterologous Systems
Pnewnocystis carinii scavenges some sterols from the host but synthesizes a large number of these compounds by de novo synthesis and modification of those it scavenges. Most of those that areExpand
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Ubiquinone Synthesis and its Regulation in Pneumocystis carinii
ABSTRACT. The opportunistic pathogen Pneumocystis causes a type of pneumonia in individuals with defective immune systems such as AIDS patients. Atovaquone, an analog of ubiquinone (coenzyme QExpand
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Modification of kinetoplast DNA minicircle composition in pentamidine-resistant Leishmania.
Pentamidine, an antiprotozoal drug, was shown to have various cellular and molecular targets depending on the organism. In Leishmania, ultrastructural modifications of kinetoplast and mitochondriaExpand
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Altered transport properties of pentamidine-resistant Leishmania donovani and L. amazonensis promastigotes
Abstract Pentamidine-resistant clones of Leishmania donovani and L. amazonensis promastigotes were developed by increase of the drug pressure in the culture medium and characterized. The resistantExpand
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Pneumocystis carinii Synthesizes Four Ubiquinone Homplogs: Inhibition by Atovaquone and Bupravaquone but not by Stigmatellin
The formation of ubiquinone (coenzyme Q, COQ, involves two separate biosynthetic pathways. The polyprenyl chain is formed by the isoprenoid pathway and the benzoquinone ring is derived from theExpand
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Evidence for Cholesterol Scavenging by Pneumocystis and Potential Modifications of Host‐Synthesized Sterols by the P. carinii SAM:SMT
Pneumoc,ysti.v carinii and P. jirovecii contain a large number of 24-alkylsterols [ 1-51. S-Adenosy1Lmethionine:sterol C-24 methyl transferase (SAM:SMT) is the enzyme that catalyzes the transfer ofExpand
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