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Antagonists for acute oral cadmium chloride intoxication.
By far the most effective in both enhancing survival and leaving minimal residual levels of cadmium in the liver and the kidney, was meso-2,3-dimercaptosuccinic acid (DMSA), while several polyaminocarboxylic acids also enhanced survival. Expand
Effect of chelate treatments on kidney, bone and brain lead levels of lead-intoxicated mice.
An examination of published data describing the effect of chelating agent treatment onbrain lead levels indicates that DMSA produces a reduction in brain lead levels under all conditions examined to date. Expand
Structural requirements for Hg(II) antidotes
Abstract A study involving (a) the structural chemistry of Hg(II) complexes with thiol containing ligands, (b) the stability constants for such systems and (c) the relative efficacy of 29 compoundsExpand
The relative nephrotoxicity of cisplatin,cis-[Pt(NH3)2(guanosine)2]2+, and the hydrolysis product of cisplatin in the rat
The lack of substantial nephrotoxicity found forcis-[Pt(NH3)2(guanosine)2)2]2+ suggests that the products resulting from the action of the DNA repair processes on platinated DNA do not contribute significantly to the neph rotoxicity of cisplatin. Expand
The role of the renin-angiotensin system in cisplatin nephrotoxicity.
The role of the renin-angiotensin system (RAS) in the pathogenesis of cisplatin nephrotoxicity was evaluated in an experimental rat model using a specific, nonpeptide angiotens in II(AII) receptor blocker, losartan, and chronic blockade of the AII receptor may improve the rate of recovery of renal function in cisPlatin-treated rats. Expand
Endophyte Infection Levels of Native and Naturalized Fescues in Illinois and England
The role of endophytes in natural systems is contingent upon infection levels that appear to vary widely among these four species, and the use of agricultural cultivars may differentially affect infection levels of naturalized plants. Expand
Structural effects in the dithiocarbamate-enhanced biliary excretion of cadmium.
Those dithiocarbamates containing hydroxyl-bearing attached groups were found to be capable of causing the greatest enhancement of the cadmium content of the bile, which varied from 30-fold to over 2000-fold. Expand
Control of nephrotoxicity in the rat during repeated cis‐platinum treatments
The use of dithiocarbamates with polar substitutents is effective in removing both renal and hepatic deposits of platinum from rats subsequent to its administration and in this respect these compounds are significantly superior to meso‐2,3‐dimercaptosuccinic acid (DMSA) in the rate at which platinum is removed and in the amounts removed. Expand
Coadministration of dimethyl sulfoxide reduces cisplatin nephrotoxicity.
The use of DMSO did not result in any observable loss in antitumor activity of cisplatin against the Walker 256 carcinosarcoma andObserved measures of nephrotoxicity which were significantly improved by the coadministration of cis Platin and D MSO over the values found for cis platin alone include BUN, serum creatinine, creatinines clearance and histopathological evidence of renal damage. Expand
Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) as an antidote for acute uranium intoxication in mice.
The low inherent toxicity of Tiron may make it appropriate for possible clinical application and survival rates for animals receiving multiple injections of T iron were enhanced over those receiving Na3CaDTPA. Expand