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Human African trypanosomiasis: pharmacological re‐engagement with a neglected disease
The challenges of chemotherapy for human African trypanosomiasis (HAT) are discussed, and the few drugs registered for use against the disease are unsatisfactory for a number of reasons.
Management of trypanosomiasis and leishmaniasis
Clinical studies with benznidazole, a drug previously recommended only for acute stage treatment, are close to completion to determine the effectiveness in the treatment of early chronic and indeterminate Chagas disease.
Glucose-induced Remodeling of Intermediary and Energy Metabolism in Procyclic Trypanosoma brucei*
The investigation of how l -proline is metabolized in glucose-rich and glucose-depleted conditions concludes that trypanosomes develop an elaborate adaptation of their energy production pathways in response to carbon source availability.
Proline Metabolism in Procyclic Trypanosoma brucei Is Down-regulated in the Presence of Glucose*
- Nadia F. Lamour, L. Rivière, V. Coustou, G. H. Coombs, M. Barrett, F. Bringaud
- BiologyJournal of Biological Chemistry
- 25 March 2005
The results indicate that the ability of trypanosomes to use proline as an energy source can be regulated depending upon the availability of glucose.
The animal trypanosomiases and their chemotherapy: a review
- Federica Giordani, L. Morrison, T. Rowan, H. D. de Koning, M. Barrett
- 10 October 2016
This review provides a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance.
IDEOM: an Excel interface for analysis of LC-MS-based metabolomics data
IDEOM provides a user-friendly data processing application that automates filtering and identification of metabolite peaks, paying particular attention to common sources of noise and false identifications generated by liquid chromatography-mass spectrometry platforms.
Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites.
Probabilistic modelling is used in conjunction with protein structural predictions and gene-structure analyses on a whole-genome scale to find gene homologies that are missed by conventional similarity-search strategies and identified a variant gene superfamily in six species of malaria (Plasmodium interspersed repeats, pir).
Topic modeling for untargeted substructure exploration in metabolomics
- J. J. van der Hooft, Joe Wandy, M. Barrett, K. Burgess, S. Rogers
- BiologyProceedings of the National Academy of Sciences
- 16 November 2016
An analytical workflow that exploits all fragmentation data from a given experiment to extract biochemically relevant features in an unsupervised manner is presented and it is demonstrated that an algorithm originally used for text mining, latent Dirichlet allocation, can be adapted to handle metabolomics datasets.
MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks
The MetExplore web server offers the possibility to link metabolites identified in untargeted metabolomics experiments within the context of genome-scale reconstructed metabolic networks, then applying graph-based methods and advanced visualization tools to enhance data analysis.