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The trypanosomiases
The trypanosomiases consist of a group of important animal and human diseases caused by parasitic protozoa of the genus Trypanosoma. In sub-Saharan Africa, the final decade of the 20th centuryExpand
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Human African trypanosomiasis: pharmacological re‐engagement with a neglected disease
This review discusses the challenges of chemotherapy for human African trypanosomiasis (HAT). The few drugs registered for use against the disease are unsatisfactory for a number of reasons. HAT hasExpand
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Management of trypanosomiasis and leishmaniasis
Background The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some,Expand
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Proline Metabolism in Procyclic Trypanosoma brucei Is Down-regulated in the Presence of Glucose*
Proline metabolism has been studied in procyclic form Trypanosoma brucei. These parasites consume six times more proline from the medium when glucose is in limiting supply than when this carbohydrateExpand
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Glucose-induced Remodeling of Intermediary and Energy Metabolism in Procyclic Trypanosoma brucei*
The procyclic form of Trypanosoma brucei is a parasitic protozoan that normally dwells in the midgut of its insect vector. In vitro, this parasite prefers d-glucose to l -proline as a carbon source,Expand
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Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites.
Functionally related homologues of known genes can be difficult to identify in divergent species. In this paper, we show how multi-character analysis can be used to elucidate the relationships amongExpand
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IDEOM: an Excel interface for analysis of LC-MS-based metabolomics data
We provide a user-friendly data processing application that automates filtering and identification of metabolite peaks, paying particular attention to common sources of noise and false identifications generated by liquid chromatography-mass spectrometry (LC-MS) platforms. Expand
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MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks
MetExplore is a web server that offers the possibility to link metabolites identified in untargeted metabolomics experiments within the context of metabolic networks. Expand
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BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei
While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolizeExpand
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Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction.
Metabolomics is an emerging field of postgenomic biology concerned with comprehensive analysis of small molecules in biological systems. However, difficulties associated with the identification ofExpand
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