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Pharmacokinetics of physostigmine in man following a single application of a transdermal system.
- K. Walter, M. Müller, M. Barkworth, A. Nieciecki, F. Stanislaus
- Medicine, BiologyBritish journal of clinical pharmacology
The pharmacokinetics of physostigmine were investigated in a three-way cross-over design in six healthy, male volunteers comparing a physostIGmine transdermal system, an oral solution and an i.v. infusion to indicate continued drug absorption from a skin depot.
Bioavailability of a new effervescent tablet of diclofenac.
- B. Terhaag, A. Hoffmann, M. Barkworth, B. Vens-Cappell
- MedicineInternational journal of clinical pharmacology…
- 1 November 2000
The new effervescent tablet of diclofenac Na shows a rapid absorption without lag time, the same amount of absorption and a slightly lower Cmax in comparison to the enteric-coated dragee, a rapid onset of therapeutic effect is postulated in acute pain disorders.
An early phase I study to determine the tolerance, safety and pharmacokinetics of idebenone following multiple oral doses.
The elimination of CV-2619 appeared to be biphasic with a mean terminal elimination half-life of 18 h, and levels of metabolites in serum were too low to provide adequate description of their elimination kinetics.
[The biological availability of cefadroxil given simultaneously with N-acetylcysteine].
According to the results, simultaneous administration of the oral cephalosporin cefadroxil and the mucolytic n-acetylcysteine is possible without changes in the bioavailability of cefADroxil being observed.
Effect of pretreatment with ranitidine on the pharmacokinetics and gastrointestinal transit of a sustained release theophylline preparation.
The data indicate that the theophylline sustained release formulation is not sensitive to the effects of major changes in gastric H+ concentration.
[The effect of bile secretion on the pharmacokinetics of a theophylline sustained-release preparation].
In vitro dissolution investigations using synthetic surfactants can predict neither food effects nor bile influence on the in vivo absorption at least for the sustained release formulation tested, as not a single case of dose dumping was observed.
Bioequivalence study of generic tablet formulations containing ethinylestradiol and chlormadinone acetate in healthy female volunteers.
Bioequivalence between test and reference formulation was demonstrated since for both ethinylestradiol and chlormadinone acetate all 90% confidence intervals of AUC(0-infinity) and Cmax fall into the generally accepted range of 80%-125%.
Effect of gallbladder contraction induced cholagogia on the pharmacokinetic profile of a sustained-release theophylline formulation.
In vitro dissolution investigations using surfactants are neither predictive of food effects nor bile influence on in vivo absorption at least for the sustained-release formulation tested.
Study on the influence of food on the absorption of theophylline from a controlled-release preparation.
As expected, the co-administration of food resulted in a physiologically determined delay in absorption, which probably is not therapeutically relevant during long-term administration.
Bioequivalence study with two different oral formulations of methocarbamol in healthy subjects. A mono-centre, comparative, randomized, open-label, single-dose, 2-way crossover study.
- R. Schlegelmilch, A. U. Eydeler, M. Barkworth, Anika Radeke
- 13 December 2011
Results of this bioequivalence trial strongly indicate that the formulations tested are bioequivalent and therefore exchangeable.