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Model for the regulation of Arabidopsis thaliana leaf margin development
Biological shapes are often produced by the iterative generation of repeated units. The mechanistic basis of such iteration is an area of intense investigation. Leaf development in the model plantExpand
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ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis
Leaf development in higher plants requires the specification of leaf initials at the flanks of a pluripotent structure termed the shoot apical meristem. In Arabidopsis, this process is facilitated byExpand
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A developmental framework for dissected leaf formation in the Arabidopsis relative Cardamine hirsuta
The developmental basis for the generation of divergent leaf forms is largely unknown. Here we investigate this problem by studying processes that distinguish development of two related species:Expand
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Control of leaf and vein development by auxin.
Leaves are the main photosynthetic organs of vascular plants and show considerable diversity in their geometries, ranging from simple spoon-like forms to complex shapes with individual leaflets, asExpand
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Pervasive robustness in biological systems
Robustness is characterized by the invariant expression of a phenotype in the face of a genetic and/or environmental perturbation. Although phenotypic variance is a central measure in the mapping ofExpand
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Arabidopsis PLETHORA Transcription Factors Control Phyllotaxis
The pattern of plant organ initiation at the shoot apical meristem (SAM), termed phyllotaxis, displays regularities that have long intrigued botanists and mathematicians alike. In the SAM, theExpand
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Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression.
Despite critical roles in development and cancer, the mechanisms that specify invasive cellular behavior are poorly understood. Through a screen of transcription factors in Caenorhabditis elegans, weExpand
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Robustness and epistasis in the C. elegans vulval signaling network revealed by pathway dosage modulation.
Biological systems may perform reproducibly to generate invariant outcomes, despite external or internal noise. One example is the C. elegans vulva, in which the final cell fate pattern is remarkablyExpand
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Quantitative Variation in Autocrine Signaling and Pathway Crosstalk in the Caenorhabditis Vulval Network
BACKGROUND Biological networks experience quantitative change in response to environmental and evolutionary variation. Computational modeling allows exploration of network parameter spaceExpand
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From genes to shape: regulatory interactions in leaf development.
In the past two years novel connections were described between auxin function and transcription factor patterning systems involved in both leaf initiation and elaboration of leaf axial patterning. AExpand
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