• Publications
  • Influence
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
TLDR
This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI and the sex-specificity of Genetic Investigation of Anthropometric Traits (GIANT) Consortium, and it is confirmed that this effect is related to weight change with age or the sexually dimorphism of body shape. Expand
Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index
TLDR
A novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals is presented and it is demonstrated that they play an important role in adult obesity. Expand
Genetic loci associated with heart rate variability and their effects on cardiac disease risk
TLDR
These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization. Expand
Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver
TLDR
Physiological and genetic interventions indicate that the hepatic estrogen receptor has a key role in this sex-related strategy that is primed around birth by the aromatase-dependent conversion of testosterone into estradiol, which is most important to direct future sex-specific dietary and medical interventions. Expand
Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide
TLDR
The gene-based analysis provided a powerful strategy to identify a locus of interest, which was not identified in the genome-wide meta-analysis because of high allelic heterogeneity, and pave the way for future investigations on new pathways and drug targets to enhance the current understanding of personalized antihypertensive treatment. Expand
Systems biology of the metabolic network regulated by the Akt pathway.
TLDR
This work will review existing metabolic models and discuss the current knowledge available to construct a kinetic model of the most relevant metabolic processes regulated by the PI3K/Akt pathway, which will enable a systems biology approach to predict the metabolic targets that may inhibit cell growth under hyper activation of Akt. Expand
Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut
TLDR
Finasteride treatment in male rats has long term effects on depressive-like behavior, hippocampal neurogenesis and neuroinflammation and gut microbiota composition. Expand
Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study
TLDR
Protective genotypes in four independent polymorphisms in PON1 could represent novel biomarkers to stratify individuals who might benefit from targeted dietary recommendation for health promotion and strategies of preventive medicine. Expand
Expanded circulating hematopoietic stem/ progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis
TLDR
Evidence is provided that expansion of circulating HSPC coupled to gene therapy can overcome the limit of stem cell harvest in osteopetrotic patients, thus opening the way to future gene-based treatment of skeletal diseases caused by BM fibrosis. Expand
...
1
2
3
4
5
...