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Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear.
- T. Bredy, H. Wu, Cortney Crego, Jessica Zellhoefer, Y. Sun, M. Barad
- Psychology, Medicine
- Learning & memory
- 1 April 2007
Extinction of conditioned fear is an important model both of inhibitory learning and of behavior therapy for human anxiety disorders. Like other forms of learning, extinction learning is long-lasting… Expand
L-Type Voltage-Gated Calcium Channels Are Required for Extinction, But Not for Acquisition or Expression, of Conditional Fear in Mice
It has been shown recently that extinction of conditional fear does not depend acutely on NMDA-type glutamate receptors, although other evidence has led to the hypothesis that L-type voltage-gated… Expand
Adrenergic transmission facilitates extinction of conditional fear in mice.
Extinction of classically conditioned fear, like its acquisition, is active learning, but little is known about its molecular mechanisms. We recently reported that temporal massing of conditional… Expand
The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear.
Histone modifications contribute to the epigenetic regulation of gene expression, a process now recognized to be important for the consolidation of long-term memory. Valproic acid (VPA), used for… Expand
An Unbiased cDNA Library Prepared from Isolated Aplysia Sensory Neuron Processes Is Enriched for Cytoskeletal and Translational mRNAs
- R. Moccia, Dillon Y. Chen, +8 authors K. Martin
- Medicine, Biology
- The Journal of Neuroscience
- 15 October 2003
Local protein synthesis is required for long-lasting synapse-specific plasticity in cultured Aplysia sensorimotor synapses. To identify synaptically localized mRNAs, we prepared a cDNA library from… Expand
Temporally massed CS presentations generate more fear extinction than spaced presentations.
- Christopher K Cain, A. Blouin, M. Barad
- Psychology, Medicine
- Journal of experimental psychology. Animal…
- 1 October 2003
Rodent fear conditioning models both excitatory learning and the pathogenesis of human anxiety, whereas extinction of conditional fear is a paradigm of inhibitory learning and the explicit model for… Expand
The L-type calcium channel blocker nifedipine impairs extinction, but not reduced contingency effects, in mice.
We recently reported that fear extinction, a form of inhibitory learning, is selectively blocked by systemic administration of L-type voltage-gated calcium channel (LVGCC) antagonists, including… Expand
Fear extinction in rodents: basic insight to clinical promise
- M. Barad
- Medicine, Psychology
- Current Opinion in Neurobiology
- 1 December 2005
Fear extinction, the reduction of fear by repeated exposure to the object of fear, is a crucial paradigm of inhibitory learning and the acknowledged preclinical model for behavior therapy of human… Expand
Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice.
Extinction of conditioned fear in animals is the explicit model of behavior therapy for human anxiety disorders, including panic disorder, obsessive-compulsive disorder, and post-traumatic stress… Expand
Understanding Trauma: Introduction: Inscribing Trauma in Culture, Brain, and Body
INTRODUCTION We live in a world torn and scarred by violence. Globalization has increased the speed and scale of conflicts and catastrophes, but violence has been integral to the human condition from… Expand