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Use of Sulfated Linked Cyclitols as Heparan Sulfate Mimetics to Probe the Heparin/Heparan Sulfate Binding Specificity of Proteins*
Compounds with short alkyl spacers effectively blocked the interaction of fibroblast growth factor-1 and lipoprotein lipase with heparin/HS, whereas longer chain spacers were required for optimal inhibition of FGF-2 and vascular endothelial growth factor binding.
Anti-Herpes Simplex Virus Activities of Two Novel Disulphated Cyclitols
By screening a library of sulphated compounds of low molecular weight, we have found that several cyclitol derivatives, each modified with two sulphate groups in addition to pyrrole and various
Analogues of SB-203207 as inhibitors of tRNA synthetases.
New processes for the synthesis of biologically relevant heterocycles
Abstract This article describes the utility of certain readily accessible, ring-fused gem-dihalogenocyclopropanes as building blocks for the synthesis of heterocyclic and biologically active
Antimicrobial and Cytotoxic Activities of Synthetically Derived Tambjamines C and E – J, BE‐18591, and a Related Alkaloid from the Marine Bacterium Pseudoalteromonas tunicata
Most tambjamine compounds showed considerable, but non‐selective, antiproliferative activity against both human cancer and normal cell lines, and tambjamines I and J displayed significant apoptosis‐inducing effects.
A concise and chemoenzymatic synthesis of (−)-gabosine A, a carba-sugar enone from Streptomycetes
The title compound 1 has been prepared, for the first time, in six steps and a completely stereo-controlled fashion from the cis-1,2-dihydrocatechol 3 in a readily available and enantiopure compound.
Convergent total syntheses of the Amaryllidaceae alkaloids lycoranine A, lycoranine B, and 2-methoxypratosine.
The title alkaloids, 1, 2, and 3 respectively, have been prepared in a convergent manner by two related routes. The superior one involves C-H functionalization of the relevant 5-methoxyindole at C-7
Synthesis of NTA3-DTDA — A Chelator-Lipid that Promotes Stable Binding of His-Tagged Proteins to Membranes
Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported, allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses.
A chemoenzymatic total synthesis of ent-bengamide E.
The cis-1,2-dihydrocatechol 3, which can be obtained in enantiomerically pure form by microbial dihydroxylation of bromobenzene, has been converted into the enantiomer, ent-1, of the