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Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer
Background: Gap junctions are intercellular channels composed of connexins, which mediate the direct passage of small molecules between neighbouring cells. They are involved in regulation of cellExpand
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Connexins 26 and 43 correlate with Bak, but not with Bcl-2 protein in breast cancer.
Apoptosis is a process associated with development and progression of breast cancer. The association between connexins and programmed cell death has only been demonstrated in a few studies. The aimExpand
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Expression of connexin 43 in breast cancer in comparison with mammary dysplasia and the normal mammary gland.
Gap junctional intercellular communication (GJIC) plays a critical role in tissue development and differentiation and probably in carcinogenesis. The purpose of the study was to evaluate theExpand
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Levels of Ve-Cadherin Increase Independently of Vegf in Preoperative Sera of Patients with Colorectal Cancer
Aims and Background Vascular endothelial cadherin (VE-cad-herin) preserves the tightness of the mature vascular network as a component of endothelial adherens junctions. Vascular endothelial growthExpand
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E-cadherin and β-catenin adhesion proteins correlate positively with connexins in colorectal cancer
The majority of solid cancers present with qualitative and quantitative aberrations of adhesion proteins, including E-cadherin and β-catenin, and connexin (Cx) gap junction proteins, which isExpand
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Leptin — From regulation of fat metabolism to stimulation of breast cancer growth
Leptin restricts intake of calories as a satiety hormone. It probably stimulates neoplastic proliferation in breast cancer, too. Growth of malignant cells could be regulated by various leptininducedExpand
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Correlation between Bcl-2 protein expression and some clinicopathological features of oral squamous cell carcinoma.
Bcl-2 inhibits most kinds of programmed cell death and provides a selective survival advantage to various cell types. The biological significance of Bcl-2 expression for the development andExpand
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Expression of connexin 26 in endometrial adenocarcinoma--analysis of correlations with some anatomoclinical features.
Alterations of gap junctional intercellular communication appear to play a role in the development and progression of cancer. Gap junction channel is composed of two connexons - hexameric unitsExpand
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Hypoxia related growth factors and p53 in preoperative sera from patients with colorectal cancer – evaluation of the prognostic significance of these agents
Abstract Background: Insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) belong to a group of hypoxia related proteins. IGF-I induces expression of VEGF and decomposesExpand
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The role of Bak expression in apoptosis of the oral squamous cell carcinoma (OSCC) and metastases to lymph nodes (LNMs).
The immunohistochemical method was applied to show Bak expression in oral squamous cell carcinoma and its metastases to lymph nodes (LNMs). Bak expression was evaluated by immunohistochemical methodsExpand
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