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A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E.
It is concluded that CD14/-159 plays a significant role in regulating serum sCD14 levels and total serum IgE levels. Expand
A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children.
Data suggest that the Arg130Gln polymorphism in IL-13, or others in close linkage with it, is associated with the development of the elevated serum IgE phenotype. Expand
Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing.
Genotyped 269 children who were participants in a longitudinal study of asthma and marked linkage disequilibrium between the beta2AR-27 polymorphism and response to albuterol was found, which may explain some of the variability in response to therapeutic doses of al buterol in children. Expand
The Monocyte/IgE Connection: May Polymorphisms in the CD14 Gene Teach Us about IgE Regulation?
In vitro IL-4-dependent IgE synthesis was strongly upregulated by LPS, but suppressed by anti-CD14 monoclonal antibodies, highlighting the complex role played by monocytes in IgE regulation. Expand
CD14: a bridge between innate immunity and adaptive IgE responses
The results suggest that genetic variation in CD14, a key gene of innate immunity, may modulate the effects that exposure to bacterial ligands has on the development of Th2 responses. Expand
A promoter polymorphism in the CD14 gene is associated with elevated levels of soluble CD14 but not with IgE or atopic diseases
Background:  A polymorphism in the promoter region of the CD14 gene, C‐159T, has been shown to be associated with increased levels of soluble CD14 (sCD14) and decreased serum immunoglobulin E (IgE)Expand
Review article CD14: an example of gene by environment interaction in allergic disease
The role of bacterial exposure in the development of the mature immune response and its modulation by a polymorphism in CD14, the gene encoding an essential component of the receptor for bacterial lipopolysaccharide (LPS, endotoxin), a key factor in the initiation of the innate immune response to bacterial infections is discussed. Expand
Factor analysis of asthma and atopy traits shows 2 major components, one of which is linked to markers on chromosome 5q.
Evidence for a locus or loci mapping to chromosome 5q31-33 associated with this composite atopic phenotype is suggested. Expand
Evaluation of the CD14 C‐159 T polymorphism in the German Multicenter Allergy Study cohort
Background Multiple genetic studies have shown linkage of atopy‐related phenotypes to chromosome 5q31. In this region several candidate genes for atopy are localized such as the Th2 cytokines IL‐4,Expand
Serum total IgE levels and CD14 on chromosome 5q31
The identification of a –159T/C promoter variant of CD14 gene, and the homozygous T alleles predicted lower serum IgE levels among Caucasian children with positive skin prick tests, support the candidacy ofCD14 as the atopy locus on chromosome 5q31. Expand