• Publications
  • Influence
Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes
Emerging data indicate that gut-derived endotoxin (metabolic endotoxemia) may contribute to low-grade systemic inflammation in insulin-resistant states. Specific gut bacteria seem to serve asExpand
  • 156
  • 10
Curcumin-induced inhibition of cellular reactive oxygen species generation: Novel therapeutic implications
There is evidence for increased levels of circulating reactive oxygen species (ROS) in diabetics, as indirectly inferred by the findings of increased lipid peroxidation and decreased antioxidantExpand
  • 226
  • 9
  • PDF
Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes
Type 2 diabetes patients exhibit subclinical inflammation but the regulatory mechanisms are poorly understood. We sought to evaluate the role of miR-146a expression along with its downstreamExpand
  • 162
  • 9
Endoplasmic reticulum (ER) stress & diabetes.
The endoplasmic reticulum (ER) is a central organelle entrusted with lipid synthesis, protein folding and protein maturation. It is endowed with a quality control system that facilitates theExpand
  • 80
  • 8
  • PDF
Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy.
OBJECTIVE Shortening of telomere length has been reported in several conditions including Type 2 diabetes and atherosclerosis. The aims of this study were (1) to assess whether telomere shorteningExpand
  • 147
  • 6
  • PDF
Imbalanced levels of angiogenic and angiostatic factors in vitreous, plasma and postmortem retinal tissue of patients with proliferative diabetic retinopathy.
A role for vascular endothelial growth factor (VEGF) has been clearly implicated in the pathogenesis of proliferative diabetic retinopathy (PDR). However, other molecules and mechanisms may beExpand
  • 65
  • 6
Improvement in glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high-fat diet-fed C57BL/6J mice
PurposeDiabetes and obesity are characterized by glucose intolerance, fat deposition, inflammation, and dyslipidemia. Recent reports postulated that distinct gut microbiota alterations were observedExpand
  • 39
  • 6
Telomere shortening occurs in Asian Indian Type 2 diabetic patients
Aim  Telomere shortening has been reported in several diseases including atherosclerosis and Type 1 diabetes. Asian Indians have an increased predilection for Type 2 diabetes and premature coronaryExpand
  • 143
  • 5
  • PDF
Telomere shortening & metabolic/vascular diseases.
Telomeres are specialized DNA-protein structures located at the ends of eukaryotic chromosomes whose length is progressively reduced in most somatic cells during ageing. Over the past decade,Expand
  • 50
  • 4
  • PDF
Oxidative stress is independently associated with non-alcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes.
OBJECTIVE Our work is aimed at exploring the interrelationship of oxidative stress and insulin resistance in NAFLD subjects with and without type 2 diabetes in a population-based study. METHODSExpand
  • 80
  • 3