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Improvement in glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high-fat diet-fed C57BL/6J mice
TLDR
Native probiotic strains MTCC 5690 and MTCC5689 appear to have potential against insulin resistance and type 2 diabetes with mechanistic, multiple tissue-specific mode of actions.
Clinical spectrum of chronic Budd‐Chiari syndrome and surgical relief for ‘coarctation’ of the inferior vena cava
TLDR
Dorsal cavoatrial bypass using a polytetra fluoroethylene graft has proved useful in Group B and interesting histopathological findings of the liver in some of the cases are also described.
Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes
TLDR
Striking message from this study is that while looking for anti-inflammatory strategies and drugs with novel mode of action for T2DM, discovering and designing specific inhibitors targeted to HDAC3 appears promising.
RELATIONSHIP OF ADIPOKINES AND PROINFLAMMATORY CYTOKINES AMONG ASIAN INDIANS WITH OBESITY AND YOUTH ONSET TYPE 2 DIABETES.
TLDR
In young Asian Indians, leptin and proinflammatory cytokines are positively, and adiponectin negatively, associated with both nonobese and obese T2DM-Y compared to nonobesity NGT individuals.
Spectrophotometric Method For The Determination Of Nimodipine In Pharmaceutical Dosage Forms
A simple and sensitive spectrophotometric method has been developed for the determination of nimodipine in bulk and pharmaceutical dosage forms. The method is based on diazotisation of reduced
High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress
TLDR
This study exposes the experimental support in that high-fructose diet is equally detrimental in causing metabolic disorders and rats subjected to high-fat/fructose diets became glucose intolerant, insulin-resistant, and dyslipidemic.
LONG‐TERM METABOLIC FUNCTION OF PANCREAS TRANSPLANTS AND INFLUENCE OF REJECTION EPISODES
TLDR
To what extent the metabolic control achieved approaches that of normal individuals, the relationships between graft endocrine and exocrine function, the effect of reversible rejection episodes on subsequent graft function, and the correlation between the results of serial tests of graft function were determined by studies at 1 month, 1 year, and 2 years in a cohort of 39 recipients.
Ventilatory response to sustained hypoxia: effect of methysergide and verapamil.
TLDR
At their maximal safe dosage in humans, methysergide and verapamil suggest no role for serotonin and calcium ions and the hypoxic response was not significantly affected by either pharmaceutical.
ALTERED CIRCULATING LEVELS OF RETINOL BINDING PROTEIN 4 AND TRANSTHYRETIN IN RELATION TO INSULIN RESISTANCE, OBESITY, AND GLUCOSE INTOLERANCE IN ASIAN INDIANS.
TLDR
Circulatory levels of RBP 4 and TTR showed a significant associations with glucose intolerance, obesity, T2DM and RBP4 additionally, with insulin resistance in Asian Indians.
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