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Characterization of a critical binding site for human polymeric Ig on secretory component.
Secretory component (SC) is an integral membrane glycoprotein of secretory epithelial cells which is responsible for the specific transport of polymeric Ig (PIg) to external mucosal surfaces. TheExpand
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Psychosocial problems in families of a child with cancer.
Eighty-one children with malignancies and their families were investigated for the psychosocial changes that take place during the course of the disease. Seventeen patients were in the initial phaseExpand
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Expression and purification of biologically active domain I of the human polymeric immunoglobulin receptor.
Previous studies using proteolytic fragments and synthetic peptides have indicated that domain I of human polymeric immunoglobulin receptor (PIgR) is necessary for ligand binding. The expression inExpand
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Psychological late effects of leukemia in children and their prevention.
The psychological and intellectual sequelae of childhood leukemia and its treatment were examined in 48 children with acute leukemia in long remission. Verbal and performance IQ values wereExpand
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Probing the topography of free and polymeric Ig-bound human secretory component with monoclonal antibodies.
Secretory component (SC), an integral membrane protein expressed on basolateral surfaces of secretory epithelial cells, mediates the transport of polymeric Ig (PIg) into external secretions. TheExpand
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Physicochemical characterization of progressive changes in the Xenopus laevis egg envelope following oviductal transport and fertilization.
Previous studies have shown that the Xenopus laevis egg envelope exists in three forms with differing ultrastructural, macromolecular, and sperm penetrability properties. The coelomic envelope (CE)Expand
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Characterization of secretory component in amniotic fluid. Identification of new forms of secretory IgA.
Amniotic fluid (AmF) contains low levels of IgA of fetal origin. Western blot analysis revealed that the major forms of IgA in human AmF contain secretory component (SC), but ranged in size betweenExpand
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Enzymatic and envelope-converting activities of pars recta oviductal fluid from Xenopus laevis.
Conversion of the coelomic egg envelope to the vitelline envelope of the Xenopus laevis egg is known to take place in the pars recta (PR) region of the oviduct. A method for collecting fluidExpand
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A conserved binding site on the receptor for polymeric Ig is homologous to CDR1 of Ig V kappa domains.
We have previously shown that the binding of human secretory component (SC) to polymeric IgA (PIgA) is inhibited by a synthetic peptide fragment of SC (SC[15-37]), and also by a mAb (mAb 6G11) whichExpand
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Neuropsychologic and CT examinations in leukemic patients surviving 10 or more years.
Long-term survivors of childhood leukemia were studied to determine their neuropsychologic status. All had had cranial irradiation 10 or more years before. The results were 1. The IQ and academicExpand
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