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MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis.
MLN64 is a protein that is highly expressed in certain breast carcinomas. The C terminus of MLN64 shares significant homology with the steroidogenic acute regulatory protein (StAR), which plays a keyExpand
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Membrane transport proteins: implications of sequence comparisons.
Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of relatedExpand
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Meta-MEME: motif-based hidden Markov models of protein families
This paper addresses that need by developing hidden Markov models which precisely model only the highly conserved regions of a family of sequences. Expand
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Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis.
Amino acid sequence comparisons reveal that tyrosine-152 and lysine-156 of Drosophila alcohol dehydrogenase (ADH) are conserved in homologous dehydrogenases, suggesting that these residues areExpand
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Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited.
Transcription and translation require a high concentration of potassium across the entire tree of life. The conservation of a high intracellular potassium was an absolute requirement for theExpand
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Characterization of Ke 6, a New 17β-Hydroxysteroid Dehydrogenase, and Its Expression in Gonadal Tissues*
The abnormal regulation of the Ke 6 gene has been linked to the development of recessive polycystic kidney disease in the mouse. In this report, we have shown that Ke 6 is a 17β-hydroxysteroidExpand
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Expansion of the mammalian 3β‐hydroxysteroid dehydrogenase/plant dihydroflavonol reductase superfamily to include a bacterial cholesterol dehydrogenase, a bacterial UDP‐galactose‐4‐epimerase, and
Mammalian 3β‐hydroxysteroid dehydrogenase and plant dihydroflavonol reductases are descended from a common ancestor. Here we present evidence that Nocardia cholesterol dehydrogenase, E. coliExpand
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Is vitellogenin an ancestor of apolipoprotein B-100 of human low-density lipoprotein and human lipoprotein lipase?
  • M. Baker
  • Biology, Medicine
  • The Biochemical journal
  • 1 November 1988
Vitellogenin, an ancient animal protein, is the major yolk protein of eggs, where it is used as a food source during embryogenesis. Here it is shown that vitellogenins, including those from theExpand
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Albumin, steroid hormones and the origin of vertebrates.
  • M. Baker
  • Biology, Medicine
  • The Journal of endocrinology
  • 1 October 2002
Albumin, the major serum protein, binds a wide variety of lipophilic compounds including steroids, other lipophilic hormones and various phytochemicals and xenobiotics that bind to receptors forExpand
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Evolutionary analysis of 11β‐hydroxysteroid dehydrogenase‐type 1, ‐type 2, ‐type 3 and 17β‐hydroxysteroid dehydrogenase‐type 2 in fish
  • M. Baker
  • Biology, Medicine
  • FEBS letters
  • 10 September 2004
Steroid dehydrogenases regulate the access of active steroids to their receptors. In particular, 11β‐hydroxysteroid dehydrogenase‐type 1 (11β‐HSD1) and 11β‐HSD2 regulate the levels ofExpand
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