• Publications
  • Influence
Amine Oxides: A Review
Amine oxides are amine-based surfactants, represent one of the smaller classes of surfactants as compared to alcohol ethoxylates and sulfonated and sulfated anionic surfactants. However, theExpand
  • 49
  • 2
Fostamatinib, a Syk inhibitor prodrug for the treatment of inflammatory diseases.
  • M. Bajpai
  • Medicine
  • IDrugs : the investigational drugs journal
  • 1 March 2009
Rigel Pharmaceuticals Inc is developing fostamatinib, a prodrug of the spleen tyrosine kinase (Syk) inhibitor R-406, for the potential treatment of autoimmune diseases such as rheumatoid arthritisExpand
  • 45
  • 1
Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model.
The synthesis and structure-activity relationship studies of a series of compounds from imidazopyridazinone scaffold as PDE7 inhibitors are disclosed. Potent analogs such as compounds 7 (31nM), 8Expand
  • 15
  • 1
Discovery of benzo[d]imidazo[5,1-b]thiazole as a new class of phosphodiesterase 10A inhibitors.
The design, synthesis and structure activity relationship studies of a series of compounds from benzo[d]imidazo[5,1-b]thiazole scaffold as phosphodiesterase 10A (PDE10A) inhibitors are discussed.Expand
  • 11
  • 1
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation.
The synthesis and structure-activity relationship studies of isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors are discussed. The pharmacokinetic profile of 10 and 21 with adequate CNSExpand
  • 15
  • 1
Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part I.
We report analogue-based rational design and synthesis of two novel series of polycyclic heteroarenes, pyrrolo[3,2-b]quinolines and pyrido[2,3-b]indoles, tethered to a biaryl system by a methyl-,Expand
  • 7
Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists.
We report the design and synthesis of novel 5,6-diarylated pyridin-2(1H)-one derivatives as pharmacophoric PDE10A inhibitors. This highly potent molecular scaffold was developed from an inactiveExpand
  • 9
Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: part II.
We report the design and synthesis of novel pyrrolo[3,2-b]quinoline containing heteroarene ethers as PDE10A inhibitors with good to excellent potency, selectivity and metabolic stability. FurtherExpand
Quantitative Interpretation of the Deviation from ‘Zero-Order’ Kinetics for the Release of Cyanocobalamin from a Starch-Based Enzymatically Degradable Hydrogel
In vitro release of the model drug Cyanocobalamin, via enzymatic degradation of a starch based semi‐interpenetrating hydrogel network, has been studied in simulated intestinal fluid (SIF) of pH 6.8Expand
  • 5