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Age-independent, gray matter-localized, brain-enhanced oxidative stress in male fischer 344 rats: brain levels of F(2)-isoprostanes and F(4)-neuroprostanes.
While studies showed that aging is accompanied by increased exposure of the brain to oxidative stress, others have not detected any age-correlated differences in levels of markers of oxidativeExpand
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Mechanism of hepatotoxicity in periportal regions of the liver lobule due to allyl alcohol: studies on thiols and energy status.
The possible involvement of thiols and adenine nucleotides in the selective toxicity to periportal regions by allyl alcohol was evaluated in isolated perfused rat livers. Infusion of allyl alcoholExpand
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Enhanced potential for oxidative stress in hyperinsulinemic rats: imbalance between hepatic peroxisomal hydrogen peroxide production and decomposition due to hyperinsulinemia.
  • L. Xu, M. Badr
  • Chemistry, Medicine
  • Hormone and metabolic research = Hormon- und…
  • 1 April 1999
Oxidative stress is involved in aging and age-related diseases. Several metabolic alterations similar to those encountered with aging and age-related diseases have been observed in response toExpand
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Interactions between plasticizers and fatty acid metabolism in the perfused rat liver and in vivo. Inhibition of ketogenesis by 2-ethylhexanol.
Rates of ketone body (beta-hydroxybutyrate plus acetoacetate) production by perfused livers from starved rats were decreased about 60% from 39 +/- 2 to 17 +/- 3 mumol/g/hr by 2-ethylhexanol (200Expand
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Disposition of cosalane, a novel anti-HIV agent, in isolated perfused rat livers.
Cosalane is a potent inhibitor of HIV replication with a broad range of activity. In this study, the hepatic disposition of cosalane was investigated with a noncirculating isolated perfused rat liverExpand
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Mechanism of hepatotoxicity to periportal regions of the liver lobule due to allyl alcohol: role of oxygen and lipid peroxidation.
The objective of this study was to evaluate the role of local oxygen tension in the zone-specific hepatotoxicity due to allyl alcohol. Infusion of allyl alcohol (350 microM) for 60 min into liversExpand
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Pharmacokinetics of the anti-AIDS drug 2',3'-dideoxyinosine in the rat.
The pharmacokinetics of 2',3'-dideoxyinosine (ddlno) was examined in the male Fischer 344 rat using reversed phase HPLC with UV and radiochemical detection. Following iv doses of 12, 25, and 100Expand
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Hepatotoxicity of menadione predominates in oxygen-rich zones of the liver lobule.
This study was designed to investigate the mechanism of zone-specific hepatotoxicity due to menadione. Infusion of menadione (64-1000 microM) into perfused livers from fasted rats caused aExpand
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Menadione causes selective toxicity to periportal regions of the liver lobule.
Infusion of increasing concentrations (0.2-1 mM) of the quinone, menadione, caused step-wise increases in oxygen uptake in perfused livers from fasted rats presumably due to oxygen-dependent redoxExpand
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Selective inhibition of hepatic peroxisomal fatty acid β-oxidation by enoximone
Abstract Although β-oxidation of fatty acids occurs in both peroxisomes and mitochondria, β-oxidizing enzymes in these organelles have distinct differences in their specifity and sensitivity toExpand
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