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Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium
TLDR
The observed non-linearities reflect the saturability of metabolic pathways and should not be of clinical relevance to the analgesic efficacy of metamizol in the dose range tested. Expand
Pharmacokinetics of single and multiple doses of clobazam in humans.
TLDR
The pharmacokinetic profile of clobazam includes time to peak levels 1--4 h after dosing, peak levels increasing linearly with the logarithm of dose, and terminal half-life of about 18 hours. Expand
Pharmacodynamic comparison of the acute effects of nomifensine, amphetamine and placebo in healthy volunteers.
TLDR
It is concluded that nomifensine showed none of those subjectively pleasant amphetamine effects which are responsible for the reinforcement function leading to amphetamine dependence. Expand
Pharmacokinetics of ramipril in the elderly.
TLDR
The mean peak concentration and half-life of Hoe 498 in serum are slightly higher in the elderly than in younger volunteers, and the mean recovery of HOE 498 and metabolites in urine, up to 26 hours after administration, was 35 +/- 14% of the dose. Expand
Pharmacokinetics and biotransformation of 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S, 5S)-2-azabicyclo [3.3.0]octane-3-carboxylic acid (Hoe 498) in rat, dog and man.
TLDR
Whereas in rat urine one metabolite dominates, the metabolite patterns in urine and serum/plasma of man and dog - which are very much alike - reveal a different biotransformation with three main metabolites. Expand
Pharmacokinetics and Pharmacodynamics of the Hydroxy-Metabolite of Glimepiride (Amaryl®) After Intravenous Administration
TLDR
The hydroxymetabolite of glimepiride shows pharmacological activity in human subjects and significantly decreased the minimum serum concentration of glucose and the average serum glucose concentration over the first four hours of treatment compared with placebo. Expand
ABSOLUTE BIOAVAILABILITY OF GLIMEPIRIDE (AMARYL®) AFTER ORAL ADMINISTRATION
TLDR
The tablet formulation of glimepiride is completely bioavailable and was safe and well tolerated in healthy volunteers and there were no statistically significant differences between mean serum pharmacokinetic parameters for the oral and intravenous formulations either with glimepire or M1. Expand
DOSE LINEARITY ASSESSMENT OF GLIMEPIRIDE (AMARYL®) TABLETS IN HEALTHY VOLUNTEERS
TLDR
The pharmacokinetics of glimepiride are dose linear in the dose range 1 to 8 mg, and glimePiride was safe and well tolerated in healthy volunteers. Expand
Determination of nomifensine by a sensitive radioimmunoassay.
TLDR
A radioimmunoassay (RIA) has been developed for determination of both nomifensine and total nom ifensine (nomifenine + conjugated nomifENSine) in serum, plasma, and urine, with high sensitivity, the requirement of small amounts of Plasma, and simple handling. Expand
Kinetic and dynamic interaction of clobazam and alcohol.
TLDR
It is concluded that combined ingestion of clobazam and alcohol is likely to be more hazardous than that of alcohol alone. Expand
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