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Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
Findings identify Mas as a functional receptor for Ang-(1–7) and provide a clear molecular basis for the physiological actions of this biologically active peptide.
Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform
The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] is causally involved in multiple central nervous facets of mood control and in regulating sleep, anxiety, alcoholism, drug abuse, food
A unique central tryptophan hydroxylase isoform.
The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)
This review highlights the current knowledge about the roles of ANG-(1–7) in physiology and disease, with particular emphasis on the brain.
Platelet-Derived Serotonin Mediates Liver Regeneration
Results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration and blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin.
Growth retardation and altered autonomic control in mice lacking brain serotonin
Telemetric monitoring revealed more extended daytime sleep, suppressed respiration, altered body temperature control, and decreased blood pressure and heart rate during nighttime in Tph2−/− mice, confirming that the majority of central serotonin is generated by TPH2.
Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents.
The data demonstrate that ES cell-derived cardiomyocytes represent a unique model to investigate the early cardiac development and permit pharmacological/toxicological studies in vitro.
Discovery and Characterization of Alamandine: A Novel Component of the Renin–Angiotensin System
Alamandine produces several physiological actions that resemble those produced by angiotensin-(1–7), including vasodilation, antifibrosis, antihypertensive, and central effects and may help to develop new therapeutic strategies for treating human cardiovascular diseases and other related disorders.
Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy.
  • M. Bader
  • Biology, Medicine
    Annual review of pharmacology and toxicology
  • 6 January 2010
Novel components with mostly opposite actions to the classical renin-angiotensin-aldosterone systems have been described and need functional characterization to evaluate their suitability as novel drug targets.