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Development of nociceptive synaptic inputs to the neonatal rat dorsal horn: glutamate release by capsaicin and menthol
To study the postnatal development of nociceptive synaptic inputs in the superficial dorsal horn of the neonatal rat spinal cord, we examined the effect of capsaicin and menthol on glutamatergic… Expand
Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons.
Little is known about the organizational and functional connectivity of the corticospinal (CS) circuits that are essential for voluntary movement. Here, we map the connectivity between CS neurons in… Expand
Development of GABAergic and Glycinergic Transmission in the Neonatal Rat Dorsal Horn
Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been… Expand
Pacemaker Neurons within Newborn Spinal Pain Circuits
Spontaneous activity driven by “pacemaker” neurons, defined by their intrinsic ability to generate rhythmic burst firing, contributes to the development of sensory circuits in many regions of the… Expand
Voltage-gated calcium currents in axotomized adult rat cutaneous afferent neurons.
The effect of sciatic nerve injury on the somatic expression of voltage-gated calcium currents in adult rat cutaneous afferent dorsal root ganglion (DRG) neurons identified via retrograde Fluoro-gold… Expand
Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury
BackgroundThe role of the neurotrophin regulated polypeptide, VGF, has been investigated in a rat spared injury model of neuropathic pain. This peptide has been shown to be associated with synaptic… Expand
Regional Differentiation of Retinoic Acid-Induced Human Pluripotent Embryonic Carcinoma Stem Cell Neurons
The NTERA2 cl D1 (NT2) cell line, derived from human teratocarcinoma, exhibits similar properties as embryonic stem (ES) cells or very early neuroepitheial progenitors. NT2 cells can be induced to… Expand
Persistent changes in peripheral and spinal nociceptive processing after early tissue injury
It has become clear that tissue damage during a critical period of early life can result in long-term changes in pain sensitivity, but the underlying mechanisms remain to be fully elucidated. Here we… Expand
Activity-dependent modulation of glutamatergic signaling in the developing rat dorsal horn by early tissue injury.
Tissue injury in early life can produce distinctive effects on pain processing, but little is known about the underlying neural mechanisms. Neonatal inflammation modulates excitatory synapses in… Expand
Excitatory synapses in the rat superficial dorsal horn are strengthened following peripheral inflammation during early postnatal development
ABSTRACT Peripheral inflammation can cause prolonged changes in pain sensitivity if it occurs during a critical period of early postnatal development, suggesting that neonatal pain circuits respond… Expand