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Chemical surface modifications for the development of silicon-based label-free integrated optical (IO) biosensors: a review.
Increasing interest has been paid to label-free biosensors in recent years. Among them, refractive index (RI) optical biosensors enable high density and the chip-scale integration of opticalExpand
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Development of oligonucleotide microarrays onto Si-based surfaces via thioether linkage mediated by UV irradiation.
Selective covalent immobilization of thiolated oligonucleotides onto an epoxy-functionalized silicon-substrate can be achieved via light radiation (365 nm). Following this approach, thiol-modifiedExpand
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PMMA isocyanate-modified digital discs as a support for oligonucleotide-based assays.
A mild chemical procedure for the derivatization of PMMA as the isocyanate on rigid supports is described. The proposal is based on spin-coating the support with a hydroxy-modified PMMA polymer,Expand
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Photoattachment of thiolated DNA probes on SU-8 spin-coated Blu-ray disk surfaces for biosensing.
A methodology to modify Blu-ray disk (BD) surfaces by spin-coating an SU-8 epoxy photoresist is evaluated, to create a hybrid material with new functionalities. The optical performance of the newExpand
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Photopolymerization as a promising method to sense biorecognition events
Abstract This work addresses the main topics related to the photopolymerization process to develop and to monitor the analytical signal derived from biorecognition assays. We review basic aspects ofExpand
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DNA Detection Using a Photonic Crystal Waveguide Sensor
We report an experimental demonstration of DNA detection using a photonic crystal waveguide based optical sensor. A detection limit of 110nM is achieved for hybridized biotinylated DNA oligomers onExpand
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Chemical derivatization of compact disc polycarbonate surfaces for SNPs detection.
Compact discs have been proposed as an efficient analytical platform, with potential to develop high-throughput affinity assays for genomics, proteomics, clinics, and health monitoring. ChemicalExpand
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Selective chemical modification of silicon nitride/silicon oxide nanostructures to develop label-free biosensors.
The selective introduction of functional groups on the surface of silicon nitride/silicon oxide nanostructures was studied. Chemical strategies based on organosilane, Si-H and N-H reactivities wereExpand
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Biphenyl macrolactams in anion complexation. Selective naked-eye fluoride recognition
Two colorimetric anion sensors 1 and 2 allow for the selective differentiation of fluoride in the presence of other anions. Two different types of species have been observed in the complexationExpand
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Direct covalent attachment of DNA microarrays by rapid thiol-ene "click" chemistry.
A rapid strategy for the covalent immobilization of DNA onto silicon-based materials using the UV-initiated radical thiol-ene reaction is presented in this study. Following this approach, thiol- andExpand
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