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Effects of the 5‐HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain
It is concluded that the 5‐HT3 receptor antagonist GR38032F, and the neuroleptic agents fluphenazine, sulpiride and haloperidol, can reduce raised mesolimbic dopaminergic activity in the rat and marmoset. Expand
GR127935: a potent and selective 5-HT1D receptor antagonist
It is concluded that GR127935 is a useful pharmacological tool to characterise 5-HT1D receptor function and has a good safety profile in all species tested. Expand
Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding
Direct evidence for the existence of 5-HT3 receptors in rat brain tissue and their distribution is reported, based on high affinity binding of the potent 5- HT3 receptor antagonist 3H-GR65630 to homogenates of rat entorhinal cortex. Expand
GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors.
GR159897 is a novel, highly potent and selective non-peptide antagonist at tachykinin NK2 receptors that should be a useful tool for studying the physiological and pathophysiological role of tachyKinin NK 2 receptor activation. Expand
5‐HT3 receptors
The psychopharmacology of 5-HT3 receptors.
The use of 5-HT3 receptor antagonists reveals an important role for 5-hydroxytryptamine in the control of disturbed behavior in the absence of effect on normal behavior. Expand
Determination of receptors that mediate opiate side effects in the mouse
It is concluded that μ‐receptor agonists may produce both their antinociceptive effects and opiate side‐effects by interacting with the μ‐ receptor. Expand
5-HT3 receptors mediate inhibition of acetylcholine release in cortical tissue
Evidence that a reduction in cortical cholinergic function can be effected in vitro by 5-HT3 receptors is provided and Radioligand binding studies show a high density of 5- HT3 receptors in theCholinergic-rich entorhinal cortex. Expand
5‐HT3 receptor antagonists injected into the area postrema inhibit cisplatin‐induced emesis in the ferret
Results confirm a role of 5‐HT, and in particular 5‐ HT3 receptors, in the control of cisplatin‐induced emesis, and show that at least one functional site for these receptors in modulating the emetic response is the area postrema, the locus of the chemoreceptor trigger zone. Expand
Failure of ondansetron to block the discriminative or reinforcing stimulus effects of cocaine in the rat.
Although other 5HT antagonists may prove to be efficacious in cocaine abuse, ondansetron appears unlikely to alter the subjective or rewarding stimulus properties of cocaine. Expand