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The pharmacophore of short cationic antibacterial peptides.
Cationic antibacterial peptides have been proclaimed as new drugs against multiresistant bacteria. Their limited success so far is partially due to the size of the peptides, which gives rise toExpand
Important structural features of 15-residue lactoferricin derivatives and methods for improvement of antimicrobial activity.
This review focuses on important structural features affecting the antimicrobial activity of 15-residue derivatives of lactoferricins. Our investigations are based on an alanine-scan of a 15-residueExpand
Antimicrobial activity of short arginine‐ and tryptophan‐rich peptides
Highly antimicrobial active arginine‐ and tryptophan‐rich peptides were synthesized ranging in size from 11 to five amino acid residues in order to elucidate the main structural requirement for suchExpand
Quantitative analysis of TEGDMA and HEMA eluted into saliva from two dental composites by use of GC/MS and tailor-made internal standards.
OBJECTIVES The use of resin-based dental restorative materials is rapidly increasing, concurrently the biocompatibility of the materials is under investigation. Attention has been placed on studiesExpand
The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the Arctic bryozoan Tegella cf. spitzbergensis.
The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2-4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. TheExpand
Antibacterial activity of 15-residue lactoferricin derivatives.
Lactoferricins are a class of antibacterial peptides isolated after gastric-pepsin digest of the mammalian iron-chelating-protein lactoferrin. For investigation of antibacterial activity, we preparedExpand
Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
LFM W8 is a synthetic 15-residue lactoferricin derivative (H2N-EKCLRWQWEMRKVGG-COOH), corresponding to residues 16-30 of the mature murine lactoferrin protein except that the asparagine residue inExpand
Antibiotic activity of pentadecapeptides modelled from amino acid descriptors
Pentadecapeptides based on modified murine lactoferricin (LFM) sequences show varying degrees of antibacterial activity against Escherichia coli and Staphylococcus aureus. By means of projections toExpand
Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway.
Benthic marine invertebrates collected from sub-Arctic regions of northern Norway, were found to be a promising source of novel bioactive compounds against human and fish pathogenic bacteria andExpand
The effects of shortening lactoferrin derived peptides against tumour cells, bacteria and normal human cells
A number of shortened derivatives of the lactoferrin model peptide L12, PAWRKAFRWAKRMLKKAA, were designed in order to elucidate the structural basis for antitumour activity of lactoferrinExpand