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Urocortin II treatment reduces skeletal muscle mass and function loss during atrophy and increases nonatrophying skeletal muscle mass and function.
TLDR
Activation of the CRF2R modulates skeletal muscle mass in both normal and atrophying muscle and may find utility in the treatment of skeletal muscle wasting diseases including age-related muscle loss or sarcopenia. Expand
Phosphodiesterase 4 inhibition reduces skeletal muscle atrophy
TLDR
Inhibitors of phosphodiesterase 4 (PDE 4), the major cAMP‐modifying PDE found in skeletal muscle, are utilized to modulate skeletal muscle cAMP levels and reduce the loss of muscle mass and force resulting from denervation and casting in rats and mice. Expand
Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions.
TLDR
A novel activity of the CRF2R is described for the first time, modulation of skeletal muscle mass, which decreased nerve damage and corticosteroid- and disuse-induced skeletal muscleMass and function loss and increased nonatrophy skeletal musclemass. Expand
Modifications of the human urocortin 2 peptide that improve pharmacological properties
TLDR
By substituting amino acid residues in the linker region of urocortin 2 (residues 22-32), improved in vivo potency is demonstrated without altering selectivity, probably through reduced CRFBP binding. Expand
Stimulation of Cyclic GMP Production via a Nitrosyl Factor in Sensory Neuronal Cultures by Algesic or Inflammatory Agents
TLDR
The findings suggest that specific exogenous substances may stimulate production of a nitrosyl factor(s) by a subset of DRG neurons, and nitroSyl factors produced by these neurons may affect cyclic GMP production in neighboring neuronal or non‐neuronal cells. Expand
Muscarinic cholinergic stimulation of the nitric oxide-cyclic GMP signaling system in cultured rat sensory neurons
TLDR
The results demonstrate that muscarinic agonists stimulate the nitric oxide-cyclic GMP signaling system in capsaicin-sensitive sensory neurons, and suggest that the noxious character of acetylcholine when administered peripherally may be mediated by nitricoxide-cyclIC GMP. Expand
Bradykinin and capsaicin stimulate cyclic GMP production in cultured rat dorsal root ganglion neurons via a nitrosyl intermediate
TLDR
Findings suggest the involvement of a nitrosyl compound in bradykinin‐and capsaicin‐stimulated cyclic GMP production and in tonic cyclicGMP production in DRG Neurons. Expand
Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response.
TLDR
A model is proposed in which stress-evoked adrenal catecholamine secretion is fine-tuned by SERT-modulated autocrine 5-HT signaling, which raises the possibility that the adrenal medulla is a previously unrecognized peripheral hub for serotonergic control of the sympathetic stress response. Expand
Corticotropin releasing factor 2 receptor agonists reduce the denervation-induced loss of rat skeletal muscle mass and force and increase non-atrophying skeletal muscle mass and force
TLDR
Results demonstrate that pharmacological modulation of the CRF2R may be a viable method to treat skeletal muscle atrophy and removal of the adrenals increased the effectiveness of the non-selective CRFR agonists sauvagine. Expand
An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells
TLDR
Carbon fibre amperometry showed that SERT modulated the ability of 5-HT1A receptors to inhibit exocytosis, revealing a novel role for SERT and suggesting that adrenal chromaffin cells might be a previously unrecognized hub for serotonergic control of the sympathetic stress response. Expand
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