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Mosaicplasty for the treatment of articular cartilage defects: application in clinical practice.
TLDR
A one-step operative technique for the treatment of circumscript cartilage defects of weight-bearing surfaces of the knee and using the modified Hospital for Special Surgery (HSS) knee scoring system, 91% of the patients achieved a good or excellent result.
Repeated biopsies in evaluation of therapeutic effects in prostate carcinoma
TLDR
The aim of this study was to determine the predictive value of some histological parameters including apoptosis and gene products which influence apoptosis, based on repeated biopsies taken from the same patients.
Apoptosis, Mitosis, p53, bcl2, Ki-67 and Clinical Outcome in Prostate Carcinoma Treated by Androgen Ablation
TLDR
The results show that the degree of induction of apoptosis in prostate carcinoma by hormonal therapy varies from case to case, and a given prostate cancer patient’s response to therapy may be predicted by following apoptotic and mitotic activity, as well as Ki-67 and p53 expression in repeated biopsies.
Pseudosarcoma in Paget's disease
TLDR
The patient received bisphosphonate treatment which decreased his pain and swelling and also the alkaline phosphatase level, and the autopsy did not prove any malignant transformation of Paget's disease of bone in the proximal femur.
Coincidence of hereditary angioedema (HAE) with Crohn's disease.
TLDR
During exacerbation of Crohn's disease, the levels of C4 was found to be significantly lower than during the periods free of symptoms of both diseases, which may indicate that the different immunopathological processes underlying HAE and Crohn’s disease influence each other.
Clinically diagnosed fatal cerebral vasculitis in long-standing juvenile rheumatoid arthritis
TLDR
The patient spent a total of 2 years and 8 months in hospitals over the 39-year course of her disease until she finally died of autoimmune cerebral vasculitis, confirmed as part of the basic immunologic disorder.
[Generalized secondary amyloidosis in rheumatoid arthritis].
TLDR
The conclusion is that the organs where there are frequently high quantities of amyloid is where the deposits begin and where there is infrequently any deposits or low quantities iswhere the deposits develop later.
Electron Microscopic Characteristics of β2-Microglobulin Amyloid Deposits in Long-Term Haemodialysis
TLDR
The loose, filamentous structure may represent an early stage of fresh, newly deposited β2-microglobulin amyloid, while the condensed and fragmented amyloidal filaments may be an advanced “mature” stage of amyloids deposition.
[Simultaneous occurrence of hereditary angioneurotic edema and Crohn disease].
TLDR
A case of the rare coincidence of hereditary angioedema (HAE) and Crohn's disease is presented and differential diagnostic pitfalls are described along with efficatious therapeutic options.
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