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Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.
The initial source of IL-4-inducing Th2 development and the mechanism of stable Th2 commitment remain obscure. We found the reduced level of IL-4 production in Stat6-deficient T cells to beExpand
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Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers
Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the early posttransplant period, andExpand
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Enrichment and detection of live antigen‐specific CD4+ and CD8+ T cells based on cytokine secretion
Following appropriate antigen‐specific stimulation, CD4+ and CD8+ T lymphocytes rapidly express cytokines. Based on this stimulation‐induced cytokine secretion and using cell suface affinity matrixExpand
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Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants.
Adoptive transfer of cytomegalovirus (CMV)-specific T cells can restore long-lasting, virus-specific immunity and clear CMV viremia in recipients of allogeneic stem cell transplants if CD4(+) andExpand
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Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans
FOXP3+ regulatory T cells (Tregs) maintain tolerance against self-antigens and innocuous environmental antigens. However, it is still unknown whether Treg-mediated tolerance is antigen specific andExpand
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Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin‐10 in interferon‐γ and in interleukin‐4‐expressing cells
In an immune response, effector functions are controlled by T helper (Th) 1 cytokines [interferon‐γ (IFN‐γ), interleukin (IL)‐2 and tumor necrosis factor‐β] and Th 2 cytokines (IL‐4, IL‐5 and IL‐10).Expand
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Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix.
We have developed a technology for analysis and sorting of live cells according to secreted molecules. An artificial affinity matrix, specific for the secreted product of interest, is created on theExpand
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Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene.
CD4 cells from mice heterozygous for an IL-4 and a GFP/IL-4 gene frequently express a single allele. Analysis of IL-4 or GFP production by cells from recently primed Th2 cells indicates thatExpand
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Correlation analysis between frequencies of circulating antigen‐specific IgG‐bearing memory B cells and serum titers of antigen‐specific IgG
Recent studies in mice have indicated that the long‐lasting specific antibody responses seen after vaccination are probably due to the existence of long‐lived plasma cells. Therefore, because theExpand
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Isolation of CD4+CD25+ regulatory T cells for clinical trials.
The adoptive transfer of donor CD4+CD25+ regulatory T cells has been shown to protect from lethal graft-versus-host disease after allogeneic bone marrow transplantation in murine disease models.Expand
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