• Publications
  • Influence
Positive selection of natural autoreactive B cells.
Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells areExpand
  • 594
  • 20
B‐cell commitment, development and selection
Summary: Here we review three areas in B‐cell development in the mouse, with a focus on relevance to B‐1/CD5+ B cells. Multiparameter flow cytometry has allowed the dissection of intermediate stagesExpand
  • 166
  • 4
Positive Selection of Anti–Thy-1 Autoreactive B-1 Cells and Natural Serum Autoantibody Production Independent from Bone Marrow B Cell Development
A natural serum autoantibody specific for the Thy-1 glycoprotein (anti–Thy-1 autoantibody [ATA]) is produced by B-1 cells that are positively selected by self-antigen. Here, using ATAμκ transgenicExpand
  • 133
  • 4
  • PDF
Evidence of marginal-zone B cell-positive selection in spleen.
Antigen receptor-mediated signaling is critical for the development and survival of B cells. However, it has not been established whether B cell development requires a signal from self-ligandExpand
  • 163
  • 4
  • PDF
Crosslinguistic Effects in L2Acquisition: Strong/Weak Resultatives and the Directional/LocationalInterpretation of PPs in L2 English by Japanese Speakers
We report on an experimental study that investigates L2 acquisition of English Strong/Weak Resultatives and the Directional/Locational interpretation of prepositional phrases (PPs) in English byExpand
  • 2
  • 2
  • PDF
Highly accumulated platelet vascular endothelial growth factor in coagulant thrombotic region
Summary.  Background: Vascular endothelial growth factor (VEGF) is an endothelial cell‐specific potent mitogen that induces angiogenesis and microvascular hyperpermeability. Recently, it has beenExpand
  • 45
  • 1
B-1 cell definition.
  • 26
  • 1
Glyceraldehyde 3-phosphate dehydrogenase is a novel autoantigen leading autoimmune responses to proliferating cell nuclear antigen multiprotein complexes in lupus patients.
Using 2-dimensional electrophoresis and ion-pair chromatography, we have identified elements of proliferating cell nuclear antigen (PCNA) multiprotein complexes that are reactive to antibodies inExpand
  • 34
  • 1
  • PDF
Suppression of ascites formation and re-accumulation associated with human ovarian cancer by an anti-VPF monoclonal antibody in vivo.
Ascites formation is often observed in ovarian cancer patients. Vascular permeability factor (VPF) may induce ascites formation. We established an animal model of ascites formation andExpand
  • 43